DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and ANPEP

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	930	Identity:	323/930 - (34%)
Similarity:	503/930 - (54%)	Gaps:	58/930 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TADSSADSIETT--YNYYRLPTSLRPQKYHLRILTLLENPED---LRFSGSVKILIEALENTKNV 76
            |..:||.:::.:  :|.||||.:|:|..|.:.:...| .|.|   ..|.||..:.....|.|..:
Human    57 TNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYL-TPNDRGLYVFKGSSTVRFTCKEATDVI 120

  Fly    77 TLHSKNLTIDESQ---ITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFA 138
            .:|||.|....||   :.||.:||....:  :..|.:....::.:::....|:..:.||:...|.
Human   121 IIHSKKLNYTLSQGHRVVLRGVGGSQPPD--IDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFE 183

  Fly   139 ADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAI 203
            .:|...|.|:|||.|.:  .|:.|.::.||.:.|.||.:|||||||..||.|.:||.:.|..||:
Human   184 GELADDLAGFYRSEYME--GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTAL 246

  Fly   204 SNM-PEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAI-- 265
            ||| |:..:.|.....::...||..:..|||||:|:.|::|.:......|..|.|.||||:||
Human   247 SNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAA 311

  Fly   266 DQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSL 330
            ...|||......:|.::...:...:||||.|||.:|||:||||||||||||||.:||:....||.
Human   312 GHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSS 376

  Fly   331 ADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLL 395
            ::|:||.:|:||||||||||||||::||.|||||||||:||..||.:...|.|...:...|:::.
Human   377 SNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVY 441

  Fly   396 TIFRRDALESSHPISRP---IQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457
            .:...|||.||||:|.|   |...::|||.||.|||.||::||||:..||.|:.|:.||.:||..
Human   442 RVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHT 506

  Fly   458 FSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERY 522
            |:|:|....|||:.|.:|.:. ||:.....::.||:.||||.|:|||.|.    ..|..|:||.:
Human   507 FAYQNTIYLNLWDHLQEAVNN-RSIQLPTTVRDIMNRWTLQMGFPVITVD----TSTGTLSQEHF 566

  Fly   523 LL--NTQVARAYR-GGCWWVPLSYTT--QAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQW 582
            ||  ::.|.|... ...|.||::...  :..||:       |:...:....|..|     ..::|
Human   567 LLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY-------WLIDVRAQNDLFST-----SGNEW 619

  Fly   583 VIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLI 647
            |:.|..::..|:||||.:||: .|:|....|...|.||||||:|:||..||...:....:|:...
Human   620 VLLNLNVTGYYRVNYDEENWR-KIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNT 683

  Fly   648 EYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQ--Q 710
            .:|..||:|:||::|..:|.....:..::..:...|.|:||.:.|::.|.....:.:..||:  .
Human   684 LFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLM 748

  Fly   711 DQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDW 775
            || ..:...::.||...|.:|.......::.|....|   .||:..|:||||||.:|..|.:.:|
Human   749 DQ-YSEVNAISTACSNGVPECEEMVSGLFKQWMENPN---NNPIHPNLRSTVYCNAIAQGGEEEW 809

  Fly   776 EFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGF 840
            :|.|.:::.:.:..|...:..||.||:|:|:|.|||..|.:| :.|||||:.....::..|.:|.
Human   810 DFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNP-DLIRKQDATSTIISITNNVIGQ 873

  Fly   841 LLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQS-----LKGLE 900
            .|...:...|...::..|...:...|.|:..::.:..|..:..:.:.|..::.::     .:.||
Human   874 GLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALE 938

  Fly   901 QAIQQTLEIMLTNVQWKERN 920
            ||:::|    ..|::|.:.|
Human   939 QALEKT----KANIKWVKEN 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	168/409 (41%)
		M1_APN_2	43..502	CDD:189008	194/470 (41%)
		ERAP1_C	583..908	CDD:288671	95/331 (29%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..62		1/4 (25%)
		Metalloprotease	69..967		320/918 (35%)
		M1_APN-Q_like	84..545	CDD:341064	190/466 (41%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269\|PubMed:1350662, ECO:0000269\|PubMed:8887485	288..295		0/6 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:22932899	352..356		3/3 (100%)
		ERAP1_C	619..946	CDD:403137	96/336 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155430
Domainoid	1	1.000	237	1.000	Domainoid score	I2322
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	LDO	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.700