DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Trhde

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	925	Identity:	291/925 - (31%)
Similarity:	470/925 - (50%)	Gaps:	97/925 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG 97
            ||...|:|..|:|.:...:||   ..|||.|.:.|.....|:.|.||:..:.:::.|:...:..|
Mouse   182 RLSGHLKPLHYNLMLTAFMEN---FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQVAEDRAFG 243

  Fly    98 EGKKENCVSSTAVNPSHDFYILNTCQELL--------AGNTYELYMPFAADLNRQLEGYYRSSYK 154
                       || |...|::....|.|:        |...|.|.:.:.|.:..:|.|::||||
Mouse   244 -----------AV-PVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSY- 295

  Fly   155 DPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD 219
             .:....:::.||||.|..||.||||||||.:||.|.:::.:...|.::|||| .||...|. ..
Mouse   296 -VIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMP-VETSVFEE-DG 357

  Fly   220 YIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAI--DQCDYAAQFGPKVLQYY 282
            ::...|.::..||||.:|:::.:|:::.:|..:..:.|.:|||:||  ...|||.....:::::|
Mouse   358 WVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFY 422

  Fly   283 EQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQ 347
            |.:|.:.:.|||:|.:|||.....|||||||..:.|..:|...:.||::....|..|:.||:.||
Mouse   423 EDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQ 487

  Fly   348 WFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLL-TIFRRDALESSHPISR 411
            |||:|||..||.|:||.||||.|...:|.:.:.|.|...:|..|:::| .:...|.|.||||:|:
Mouse   488 WFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASSHPVSQ 552

  Fly   412 PIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAA 476
            .:...::|...||.|:|:||:.::||:..|:|...|:.|||.||....|.||.:::||.:|::|
Mouse   553 EVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEA- 616

  Fly   477 HKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGC----- 536
              .|...|..:|:.:||.||||.|||||.:..:..|       |..:|.||....|..|.
Mouse   617 --LRRNGKYVNIQEVMDQWTLQMGYPVITILGNTTA-------ENRILITQQHFIYDIGAKTKAL 672

  Fly   537 --------WWVPLS--------YTTQAVQDFNNTAPK---AWMECGKNGESLPKTIQDLPGPDQW 582
                    |.:||:        .:::|:...:|.:..   |:::.|                 .|
Mouse   673 QLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRIAYLDRG-----------------SW 720

  Fly   583 VIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLI 647
            ::.|...:..::||||.:||:|||:.|.. :.|.:.|.|||.|||||..||..|.....|.:.:|
Mouse   721 ILGNINQTGYFRVNYDLRNWRLLIDQLIR-NHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEII 784

  Fly   648 EYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHL----NGINDTFSAIP 708
            .||..|:::|||.:|...|..:.:::.:..::..|..|:.|.:...|..|    |..|.:.....
Mouse   785 RYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQAS 849

  Fly   709 QQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDS 773
            .|.:. |:..|:..||.:....|..||.....:|.:    ..:|.:|:|||..||||.:....:.
Mouse   850 YQHEE-LRREVIMLACSFGNKHCHQQASTLISDWIS----SNRNRIPLNVRDIVYCTGVSLLDED 909

  Fly   774 DWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEV 838
            .|||:|.::..:...:||:.:|.||.||.:..||.|.|.|:.: .|.:..||::.....||.|..
Mouse   910 VWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLN-SEVVLDQDAIDVIIHVARNPH 973

  Fly   839 GFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQA- 902
            |..||.|:|.|....:...|.......|:|:|.::|.:.|..:..|.|:|:    :|..|:..|
Mouse   974 GRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM----KSYDGVASAS 1034

  Fly   903 IQQTLEIMLTNVQWK 917
            ..:.:|.:..||:||
Mouse  1035 FSRAVETVEANVRWK 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	139/408 (34%)
		M1_APN_2	43..502	CDD:189008	164/469 (35%)
		ERAP1_C	583..908	CDD:288671	99/329 (30%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	160/466 (34%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	101/334 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950