DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and LVRN

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	957	Identity:	296/957 - (30%)
Similarity:	447/957 - (46%)	Gaps:	96/957 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SSADSIETT-----------YNYYRLPTSLRPQKYHLRILTLLENPE----DLRFSGSVKILIEA 69
            |||..:..|           ::..|||..|.|..|.|.:...|...|    .|.|:|.|.|.:..
Human    73 SSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRC 137

  Fly    70 LENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNP-----SHDFYILNTCQELLAGN 129
            ...|..:.|||  |..|..:..:|.....|.....|....|:.     ..::.:|...:.|..|:
Human   138 TVATSRLLLHS--LFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGS 200

  Fly   130 TYELYMPFAADLNRQL-EGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVT 193
            :|||.:.|:..:...| ||.:.:.|.|  ....:.:..:|.||..||..|||||||..||.|.:|
Human   201 SYELQLSFSGLVKEDLREGLFLNVYTD--QGERRALLASQLEPTFARYVFPCFDEPALKATFNIT 263

  Fly   194 LGYHKKYTAISNMPEKETKPHETLADYIW--CEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALF 256
            :.:|..|.|:||||:......|.:....|  ..|..:..|.|||||:.:.|:.|...|.....:
Human   264 MIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEI- 327

  Fly   257 RTWARPNAI--DQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREI 319
            |.|||.:||  ...|:|......:..:.|..|.|.:.|||.|.||:|.|...|||||||:.:.|.
Human   328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDES 392

  Fly   320 ALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWR 384
            .||..........|..::.||:||:.||||||||||.||.::|||||||:|.....:...||: .
Human   393 GLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPK-L 456

  Fly   385 SMEQESLSNLL-TIFRRD-ALESSHPISRPIQM------VSEISESFDQISYQKGSTVLRMMHLF 441
            ...:...||:| .|.|.| ||     ::|.:.|      .|||.|.||..:|.||:::.||:..|
Human   457 PRNEIFFSNILHNILREDHAL-----VTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCF 516

  Fly   442 LGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINV 506
            |.|..|.|.|::||:.|||.|||||:||.....|.....::.....||:||||||.|:|:|||.:
Human   517 LNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITL 581

  Fly   507 TRDYAARTAKLNQERYLLNTQVARAY--RGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESL 569
            .    ..|..:.||.:.|.....|..  ....|.||:.:...     ..|.|..|::  ::.:..
Human   582 N----VSTGVMKQEPFYLENIKNRTLLTSNDTWIVPILWIKN-----GTTQPLVWLD--QSSKVF 635

  Fly   570 PKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAW 634
            |: :|.......|||.|..::..|:||||...||.|.:.|.. |.:.|.||:|.||||||..|:.
Human   636 PE-MQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEK-DPKAIPVIHRLQLIDDAFSLSK 698

  Fly   635 TGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGR-IVRQTPDFEFF---KRYMKK---LILP 692
            ....:.|.|:.|.:||..|.|.:.|.:...||  |.| :|.:...::.:   |||:.|   ||..
Human   699 NNYIEIETALELTKYLAEEDEIIVWHTVLVNL--VTRDLVSEVNIYDIYSLLKRYLLKRLNLIWN 761

  Fly   693 IY-----EHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKN 752
            ||     |::..:.|.:.|:     :.|:.:.|. ||...:.||:..:...:..|  ..:|:  |
Human   762 IYSTIIRENVLALQDDYLAL-----ISLEKLFVT-ACWLGLEDCLQLSKELFAKW--VDHPE--N 816

  Fly   753 PVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDP 817
            .:|..::..|.|..|..|||.:|:.|...|..:....||..:..|:.||::.|:|.||:|.....
Human   817 EIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAIST 881

  Fly   818 KEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDF 882
            ......:.::  .:.||.:|||..:||.:.::|...:.|.|.  |:.:..|:..:...|.|....
Human   882 SPFTSNETNI--IEVVASSEVGRYVAKDFLVNNWQAVSKRYG--TQSLINLIYTIGRTVTTDLQI 942

  Fly   883 NEFKDFVNNSRQ---------SLKGLEQAIQQTLEIMLTNVQWKERN 920
            .|.:.|.:|..:         :|:.::....:..::......|..||
Human   943 VELQQFFSNMLEEHQRIRVHANLQTIKNENLKNKKLSARIAAWLRRN 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	144/419 (34%)
		M1_APN_2	43..502	CDD:189008	172/480 (36%)
		ERAP1_C	583..908	CDD:288671	95/345 (28%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		4/17 (24%)
		Peptidase_M1	97..506	CDD:279741	144/419 (34%)
		M1_APN_2	105..577	CDD:189008	172/482 (36%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	93/319 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750