DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and ENPEP

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001968.3	Gene:	ENPEP / 2028	HGNCID:	3355	Length:	957	Species:	Homo sapiens

Alignment Length:	935	Identity:	304/935 - (32%)
Similarity:	482/935 - (51%)	Gaps:	100/935 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHS 80
            |:.|.|..     :..:|||..:.|..|.|.:..|||  || .::|:|.|.|.....|:.:.||.
Human    80 ASEDESGQ-----WKNFRLPDFVNPVHYDLHVKPLLE--ED-TYTGTVSISINLSAPTRYLWLHL 136

  Fly    81 KNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGN---TYELYMPFAADLN 142
            :...|.......|..|.:.:...|..    ....::.::...:||...:   .|.|.|.||..||
Human   137 RETRITRLPELKRPSGDQVQVRRCFE----YKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLN 197

  Fly   143 RQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMP 207
            ..|.|:||::|.:  ....|.|..|..||..||.:|||||||:.||.:.:::.:.|:|.|:||||
Human   198 GSLVGFYRTTYTE--NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMP 260

  Fly   208 EKETKPHETLADYIWCE--FQESVPMSTYLVAYSVNDF--------SHKPSTLPNSALFRTWARP 262
            ..:    |...|..|..  |::|||||||||.::|:.|        |.||.|:        :.:|
Human   261 VAK----EESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTI--------YVQP 313

  Fly   263 NAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAH 327
            ......:|||.....|..|:|::|.:.:.|||:|:||:|||..||||||||:||||..|||....
Human   314 EQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKE 378

  Fly   328 SSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLS 392
            |:.:::||||:||||||.||||||:|||.||.|||||||||::...|||.:...:|:..:|..|.
Human   379 SASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLE 443

  Fly   393 NLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457
            ::|.:...|:|.|||||...:....||:..||.|||.|||::|||:..::..|:|:.|.|.||:|
Human   444 DVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEK 508

  Fly   458 FSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERY 522
            :.:|||:..:.|.:|.:|:.    ||    :|.:||:||.|.||||:||.     ....:.|:|:
Human   509 YQFKNAKTSDFWAALEEASR----LP----VKEVMDTWTRQMGYPVLNVN-----GVKNITQKRF 560

  Fly   523 LL----NTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWV 583
            ||    |.....:..|..|.:|:.:|     :.|.|:...:....|.|.:|..:   .|..:.::
Human   561 LLDPRANPSQPPSDLGYTWNIPVKWT-----EDNITSSVLFNRSEKEGITLNSS---NPSGNAFL 617

  Fly   584 IFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIE 648
            ..|......|:|||:...|. .|.|..:.:.:.....:||.|||||..||.....||::|:.|.:
Human   618 KINPDHIGFYRVNYEVATWD-SIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTK 681

  Fly   649 YLQREREYLPWK----------SAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDT 703
            ||:||..:|||:          |.||:.|.:         :...:.|.:..:.||.:.| |.||.
Human   682 YLKREENFLPWQRVISAVTYIISMFEDDKEL---------YPMIEEYFQGQVKPIADSL-GWNDA 736

  Fly   704 FSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIK 768
            ...:.:    ||::.|:.:||:....:.:..|.:.:..|.     :....:|:|:|..||...::
Human   737 GDHVTK----LLRSSVLGFACKMGDREALNNASSLFEQWL-----NGTVSLPVNLRLLVYRYGMQ 792

  Fly   769 H-GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQA 832
            : |::..|.:...:|:|:::|.||..:|..|...:.|.||.|||:|..| ...|:.||.....:.
Human   793 NSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKD-TNLIKTQDVFTVIRY 856

  Fly   833 VAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLK 897
            :::|..|..:|..:...|.|::...|....:::.|::: ::|...|.....:.:.|.....|:..
Human   857 ISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFFAKYPQAGA 920

  Fly   898 GLEQAIQQTLEIMLTNVQW--KERN 920
            | |:..:|.||.:..|::|  :.||
Human   921 G-EKPREQVLETVKNNIEWLKQHRN 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	162/410 (40%)
		M1_APN_2	43..502	CDD:189008	186/471 (39%)
		ERAP1_C	583..908	CDD:288671	85/335 (25%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..83		1/2 (50%)
		Peptidase_M1	92..482	CDD:279741	162/410 (40%)
		M1_APN_2	100..545	CDD:189008	186/473 (39%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23888046, ECO:0007744\|PDB:4KXA, ECO:0007744\|PDB:4KXB, ECO:0007744\|PDB:4KXC, ECO:0007744\|PDB:4KXD	357..361		3/3 (100%)
		ERAP1_C	617..931	CDD:288671	86/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820