Protein Alignment SP1029 and Npepps

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_032968.2
• Gene: Npepps / 19155
• MGIID: 1101358
• Length: 920
• Species: Mus musculus
• Alignment Length: 936
• Identity: 297/936 - (31%)
• Similarity: 464/936 - (49%)
• Gaps: 82/936 - (8%)

  Fly    13 LGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPE--DLRFSGSVKILIEALENTKN 75
            ||||.......       :.|||..:.|..|.|.:     .|:  |..|.|.::...:..:.|..
Mouse    41 LGLAAMPEKRP-------FERLPAEVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQ 93

  Fly    76 VTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVN-PSHDFYILNTCQELLAGNTYELYMPFAA 139
            :.::..::.|    || .....||.:|  :.:|..| .:.|..:..:....|...|..|.:.|..
Mouse    94 IVMNCADIDI----IT-ASYAPEGDEE--IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 151

  Fly   140 DLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAIS 204
            :||.:::|:|||.|..| |...::.:|||||...||.||||:|||..||.|.::|...|...|:|
Mouse   152 ELNDKMKGFYRSRYTTP-AGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 215

  Fly   205 NMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCD 269
            ||...:.||:....:.:..:|..:..|||||||:.|.::....:...:....|.:......:|..
Mouse   216 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 280

  Fly   270 YAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQ 334
            :|.:...|.|.:|:.:|.:.:||||||.||:.||:||||||||||||||.|||....:|..:.:|
Mouse   281 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 345

  Fly   335 RVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFR 399
            .||.||.||||||||||||||:|||.||||||||:::..|.|::..||:....|...::......
Mouse   346 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 410

  Fly   400 RDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAE 464
            .|||::||||...:...||:.|.||.|||.||::|:||:|.::|::.|:.|:..||.||..|||.
Mouse   411 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 475

  Fly   465 QDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAA--RTAKLNQERYLLNTQ 527
            .::|||||..|:.|        .|.::|::||.|.|:|:|.|..:...  |..||:|:::
Mouse   476 TEDLWESLESASGK--------PIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKF----- 527

  Fly   528 VARAYRGG--C--WWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQ 588
            .|....||  |  |.||::.:|.  :|.|....|..|:..:....| |.::    |||||..|..
Mouse   528 CASGPYGGEDCPQWMVPITISTS--EDPNQAKLKILMDKPEMSVVL-KNVK----PDQWVKLNLG 585

  Fly   589 LSTLYKVNYDAQNWKLLIETLTNG--DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQ 651
            ....|:..|.:    .::|:|..|  |.. :..::|..|.:|...||..|.......::::|...
Mouse   586 TVGFYRTQYSS----AMLESLLPGIRDLS-LPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFV 645

  Fly   652 REREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQV--L 714
            .|..|..|.....||..:..::..|..:|..:.::|.:..||.|.|.     :...|.:..:  |
Mouse   646 NEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLG-----WDPKPGEGHLDAL 705

  Fly   715 LKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLW 779
            |:.:|:.     ::|....:|.......|.:.:.:.|..:..::||.||.|.:|||..:..:.:.
Mouse   706 LRGLVLG-----KLGKAGHKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGATLDIML 765

  Fly   780 TRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVA-FNEVGFLLA 843
            ..:|::::..||..|...||.:....|:|:.  |||...|.:|.||::.....|| .::.|...|
Mouse   766 KLHKQADMQEEKNRIERVLGATLSPELIQKV--LTFALSEEVRPQDTVSVIGGVAGGSKHGRKAA 828

  Fly   844 KKYFMDNVDFIYKFYHP--LTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQT 906
            .|:..||.:.::..|..  |   :|||:....|.........|.|.|..:  ......|:.|||.
Mouse   829 WKFIKDNWEELHNRYQGGFL---ISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQC 888

  Fly   907 LEIMLTNVQWKERNYHQMSRSIQQLL 932
            .|.:|.|..|.:|:    :.||.|.|
Mouse   889 CENILLNAAWLKRD----ADSIHQYL 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	174/457 (38%)
		ERAP1_C	582..910	CDD:463368	80/334 (24%)
Npepps	NP_032968.2	M1_APN-Q_like	62..500	CDD:341064	174/458 (38%)
		ERAP1_C	579..892	CDD:463368	80/334 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		1/3 (33%)