DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP1029 and Npepps

DIOPT Version :9

Sequence 1:NP_001263065.1 Gene:SP1029 / 53473 FlyBaseID:FBgn0263236 Length:932 Species:Drosophila melanogaster
Sequence 2:NP_032968.2 Gene:Npepps / 19155 MGIID:1101358 Length:920 Species:Mus musculus


Alignment Length:936 Identity:297/936 - (31%)
Similarity:464/936 - (49%) Gaps:82/936 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPE--DLRFSGSVKILIEALENTKN 75
            ||||.......       :.|||..:.|..|.|.:     .|:  |..|.|.::...:..:.|..
Mouse    41 LGLAAMPEKRP-------FERLPAEVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQ 93

  Fly    76 VTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVN-PSHDFYILNTCQELLAGNTYELYMPFAA 139
            :.::..::.|    || .....||.:|  :.:|..| .:.|..:..:....|...|..|.:.|..
Mouse    94 IVMNCADIDI----IT-ASYAPEGDEE--IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 151

  Fly   140 DLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAIS 204
            :||.:::|:|||.|..| |...::.:|||||...||.||||:|||..||.|.::|...|...|:|
Mouse   152 ELNDKMKGFYRSRYTTP-AGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 215

  Fly   205 NMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCD 269
            ||...:.||:....:.:..:|..:..|||||||:.|.::....:...:....|.:......:|..
Mouse   216 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 280

  Fly   270 YAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQ 334
            :|.:...|.|.:|:.:|.:.:||||||.||:.||:||||||||||||||.|||....:|..:.:|
Mouse   281 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 345

  Fly   335 RVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFR 399
            .||.||.||||||||||||||:|||.||||||||:::..|.|::..||:....|...::......
Mouse   346 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 410

  Fly   400 RDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAE 464
            .|||::||||...:...||:.|.||.|||.||::|:||:|.::|::.|:.|:..||.||..|||.
Mouse   411 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 475

  Fly   465 QDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAA--RTAKLNQERYLLNTQ 527
            .::|||||..|:.|        .|.::|::||.|.|:|:|.|..:...  |..||:|:::     
Mouse   476 TEDLWESLESASGK--------PIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKF----- 527

  Fly   528 VARAYRGG--C--WWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQ 588
            .|....||  |  |.||::.:|.  :|.|....|..|:..:....| |.::    |||||..|..
Mouse   528 CASGPYGGEDCPQWMVPITISTS--EDPNQAKLKILMDKPEMSVVL-KNVK----PDQWVKLNLG 585

  Fly   589 LSTLYKVNYDAQNWKLLIETLTNG--DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQ 651
            ....|:..|.:    .::|:|..|  |.. :..::|..|.:|...||..|.......::::|...
Mouse   586 TVGFYRTQYSS----AMLESLLPGIRDLS-LPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFV 645

  Fly   652 REREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQV--L 714
            .|..|..|.....||..:..::..|..:|..:.::|.:..||.|.|.     :...|.:..:  |
Mouse   646 NEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLG-----WDPKPGEGHLDAL 705

  Fly   715 LKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLW 779
            |:.:|:.     ::|....:|.......|.:.:.:.|..:..::||.||.|.:|||..:..:.:.
Mouse   706 LRGLVLG-----KLGKAGHKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGATLDIML 765

  Fly   780 TRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVA-FNEVGFLLA 843
            ..:|::::..||..|...||.:....|:|:.  |||...|.:|.||::.....|| .::.|...|
Mouse   766 KLHKQADMQEEKNRIERVLGATLSPELIQKV--LTFALSEEVRPQDTVSVIGGVAGGSKHGRKAA 828

  Fly   844 KKYFMDNVDFIYKFYHP--LTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQT 906
            .|:..||.:.::..|..  |   :|||:....|.........|.|.|..:  ......|:.|||.
Mouse   829 WKFIKDNWEELHNRYQGGFL---ISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQC 888

  Fly   907 LEIMLTNVQWKERNYHQMSRSIQQLL 932
            .|.:|.|..|.:|:    :.||.|.|
Mouse   889 CENILLNAAWLKRD----ADSIHQYL 910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP1029NP_001263065.1 Peptidase_M1 33..431 CDD:279741 152/400 (38%)
M1_APN_2 43..502 CDD:189008 177/461 (38%)
ERAP1_C 583..908 CDD:288671 78/331 (24%)
NpeppsNP_032968.2 Peptidase_M1 54..442 CDD:279741 152/400 (38%)
M1_APN_2 62..505 CDD:189008 177/463 (38%)
Substrate binding. /evidence=ECO:0000250 317..321 3/3 (100%)
ERAP1_C 580..891 CDD:288671 78/332 (23%)
Nuclear localization signal. /evidence=ECO:0000255 727..731 1/3 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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