Protein Alignment SP1029 and T12E12.6

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_500831.2
• Gene: T12E12.6 / 188454
• WormBaseID: WBGene00020465
• Length: 641
• Species: Caenorhabditis elegans
• Alignment Length: 637
• Identity: 146/637 - (22%)
• Similarity: 247/637 - (38%)
• Gaps: 147/637 - (23%)

  Fly    35 PTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVT-----LHS-KNLTI----DESQ 89
            |.::.|..|.|  |..|...|...|:||:.:.......:.|:|     ||| :|:::    |.::
 Worm    19 PHNIIPLSYDL--LFKLPIHEFNGFTGSMVLHFNLSSLSDNITLDAVDLHSFRNISLIRSADLTE 81

  Fly    90 ITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYK 154
            .||:.|....:|.......::.|.         |.||....|.      ..:....|..:..  :
 Worm    82 PTLKSIKILKEKVELKFEKSLFPG---------QYLLTIGEYN------GRIGNSSEALFER--R 129

  Fly   155 DPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD 219
            :|:      :..|..:|..||..|||.|.|..||.|.:::.:.....|.||          |:|.
 Worm   130 NPL------LYTTHLQPNHARRLFPCIDHPAVKALFRLSIVHPTDTVAQSN----------TIAM 178

  Fly   220 YIWCE--------FQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGP 276
            .:..|        ||.:..:..||||:||         :|:|.|           |......||.
 Worm   179 DVHVENRKWQRTIFQATPLLPAYLVAFSV---------MPDSNL-----------QLSRQTSFGV 223

  Fly   277 KV-----------------LQYYEQFFG---IKFPLPKIDQIAVPDFSAGAMENWGLVTYREIAL 321
            .|                 |..:|...|   :..||.|||.|.||::. |.|||||.:|..|..
 Worm   224 TVRVNGESRGLVLRVLDCALASFEILAGLIDVPLPLNKIDFILVPEYD-GGMENWGHITVSETL- 286

  Fly   322 LYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSM 386
                  ::..|...:..::|||:||.|.||..|:..|..:.|.|....::|...|:.:..:...:
 Worm   287 ------ATSGDDAHLIYLIAHEIAHHWIGNRATIDSWNWICLQEDLTDWMALKAVKALLTDEIRL 345

  Fly   387 EQESLSNLLTI-FRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSG 450
            ::..|:..:.| ...|.|...|.:..|.::..|:   .::..|.||..:|..:...:||:...|.
 Worm   346 QRFQLAQYVEIQLVEDFLSPGHSLYMPSKINQEL---INRHCYLKGVVLLDTLESVVGEQFMYSV 407

  Fly   451 LQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTA 515
            :::.:...|..|.      .:.|....:.| :.::..:..|.:.|....|||.|.|..:  ..::
 Worm   408 IKSLVGSHSTYNL------TTFTSYFDQIR-VDRNATVGQIYEYWYTTGGYPSILVENN--GPSS 463

  Fly   516 KLNQERYLLNTQVARAYRGGCWWVPLSYT-TQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGP 579
            :|.        |::|..     | ||..| |.|:..|            ...||:....::.|
 Worm   464 RLQ--------QLSRPL-----W-PLKMTSTLAIPQF------------VFSESIVFASENAP-- 500

  Fly   580 DQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALY 631
               ::.|...::..:||||:..|..:.:.:.. :.|....:.||||:.|..|
 Worm   501 ---LLVNLNFTSFMRVNYDSLTWTAIFKYMFE-EPELFSAVGRAQLVSDFCY 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	113/493 (23%)
		ERAP1_C	582..910	CDD:463368	13/50 (26%)
T12E12.6	NP_500831.2	GluZincin	25..402	CDD:472708	105/442 (24%)