DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and anp-1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	943	Identity:	297/943 - (31%)
Similarity:	470/943 - (49%)	Gaps:	87/943 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRILTLL------ENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQIT 91
            |||||:.|..|.|.:.|.|      .:..:|.|.|.|.|.:...::.|.|:|:||:|...|..|.
Worm    85 RLPTSVSPISYQLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDLNYTEEFIK 149

  Fly    92 LRQIGGEGKKENCVSSTA--VNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYK 154
            ...|...||.   ::.|.  ...:|:....|..:.:....:..|.:.|.|.|...:.|.|:::|.
Worm   150 KSSILVNGKS---IAFTLDDKQSTHEKIFFNLDETVEPTTSATLKVAFGAPLRTDMSGLYQTTYT 211

  Fly   155 DPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD 219
            :.... :|..:|||.||..||...||||||.:||.:.||:.:..|..|:||  ..|.|..:....
Worm   212 NSKGE-SKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSN--GIEDKVEDGQPG 273

  Fly   220 YIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQ 284
            :|...|:.:..||:||:|..:::|.:..:|..:...||.|:||...:...||.:.|.|.|:|||:
Worm   274 FIISTFKPTPRMSSYLLAIFISEFEYNEATTKSGVRFRVWSRPEEKNSTMYAVEAGVKCLEYYEK 338

  Fly   285 FFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWF 349
            ::.|.|||||.|.:|:|||||||||||||:||||.||||.....|.:.|:|||.|:|||||||||
Worm   339 YYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVAVVIAHELAHQWF 403

  Fly   350 GNLVTMKWWTDLWLNEGFATYVASLGVENINP------EWRSMEQESLSNLLTIFRRDALESSHP 408
            |||||:|||.||||||||||.|..||.:.|:.      ||.:|:.     |.:....|::.|:||
Worm   404 GNLVTLKWWNDLWLNEGFATLVEYLGTDEISDGNMRMREWFTMDA-----LWSALAADSVASTHP 463

  Fly   409 ISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLT 473
            ::..|....|:.:|||.::|.||..||.|:...:|||:|.:|:..||.:..:.||:..||..:|.
Worm   464 LTFKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYLTRHQFDNADAGNLLTALG 528

  Fly   474 QAAHKYRSLPK--SYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERY-LLNT-----QVAR 530
            :........||  ..:|...||.||.|.|||::|.:|....... :.|.|: ||.|     :.:.
Worm   529 EKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTHII-VEQSRFKLLATGKEEEKYSN 592

  Fly   531 AYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKV 595
            ...|..|.||:.|......:..    ..||   |..|  |..|:.    |:.||.|.:.:..|:.
Worm   593 PVWGFKWDVPVWYQVVGSSELE----MKWM---KRNE--PLIIKS----DKNVIINAESNGFYRA 644

  Fly   596 NYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWK 660
            .|.:..||.:.|.|.. :.|:.....|.:||||:..||..|...|.|.:.||.||:.|:|||||.
Worm   645 GYSSGLWKEISEMLKE-NHEQFSPQTRVRLIDDSFALARAGLLSYSIPLNLITYLKNEKEYLPWS 708

  Fly   661 SAFENLKRVGRIVRQTPDFEFFKRYMKKLI--LPIYEHLNGINDT------FSAIPQQDQVLLKT 717
            .|...::.:..:....|:.:...::|..|.  .|....::.::..      |..:....|::|.
Worm   709 GAIAKIRELIDMYGSNPEKDIVNKFMIALAENAPARRSIDFVSKNYLDEKKFYEVGAAQQIILN- 772

  Fly   718 MVVNWACQYQVGDCVPQA----------LAYYRNWRAEANP--DEKNPVPINVRSTVYCTSIKHG 770
                 :|.:  ||.|.||          ||     :.:|..  .|.:.:|...|:..||.::::|
Worm   773 -----SCGF--GDSVCQADMVKMFTEEVLA-----KCDATRILSECSQIPAPFRAESYCEAVRNG 825

  Fly   771 SDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPK-EAIRKQDSMWAFQAVA 834
            :...:|.::..||......||..::|||.||:::..|::.|.....|: .:.|.||....|..::
Worm   826 NSDTFEKVFHWYKTERNQVEKLNLMTALTCSKDILTLKKLLLDAMKPEGSSFRLQDCAALFAKIS 890

  Fly   835 FNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNS-RQSLKG 898
            .|:........:.:|..:.:.|.........||:||.:...:.|....::.:.|...: :.|..|
Worm   891 SNDATTDAMLNFLIDRWEDMQKRLATDHSGFSRVLSSIVNTLKTRGGLDQLRKFRKKAPKASEFG 955

  Fly   899 LEQAIQQTLEIMLTNVQWKERNYHQMSRSIQQL 931
            |:: ::::.|:.:|   |:|.|...:::.|:::
Worm   956 LDK-MEESAEVTVT---WRETNLKFVTKIIEEI 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	162/411 (39%)
		M1_APN_2	43..502	CDD:189008	182/474 (38%)
		ERAP1_C	583..908	CDD:288671	82/346 (24%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	162/411 (39%)
		M1_APN_2	93..559	CDD:189008	182/476 (38%)
		ERAP1_C	632..964	CDD:288671	82/346 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H114373
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920