Protein Alignment SP1029 and AC3.5

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_001256214.1
• Gene: AC3.5 / 179447
• WormBaseID: WBGene00007071
• Length: 1090
• Species: Caenorhabditis elegans
• Alignment Length: 1030
• Identity: 225/1030 - (21%)
• Similarity: 412/1030 - (40%)
• Gaps: 224/1030 - (21%)

  Fly    18 ADSSADSIETTYNYYRLPTSLRPQKY-----------------HLRI------LTLLENPEDLRF 59
            ||.:|...:.|.....||.:::|..|                 |:::      ..::.|.:|:.|
 Worm   140 ADENASIKQPTKEELALPKNVQPVWYDVSLSPKVGGNGTMGLAHVKLNIEEPTNKIVLNAKDIEF 204

  Fly    60 SGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTA-------VNPSHDF- 116
            :.:    :|.::.:|.||..:|. ::|....:..:: .||..|..:::||       ..|...|
 Worm   205 TRN----LEKIQLSKEVTKRAKK-SVDSGTNSTSEM-PEGSGEEAMATTATTTTTESTTPVSSFV 263

  Fly   117 -----------------YILNTCQELLAGNTYELYMPFAADL--NRQLEGY-YRSSYKDPVANLT 161
                             ..|...|||..|:|..|.:||.:.:  |..|:.| |::|.....:..|
 Worm   264 DTGIKVTNIEFDENLEKVTLTLDQELKKGSTVVLKIPFTSKVSNNNGLKEYKYKNSEGKEQSMFT 328

  Fly   162 KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETK-------------- 212
                 ||...:..|..||.||:..||||..:||.:.|....::|...| ||
 Worm   329 -----TQPSYSYLRHVFPSFDQEAFKAPAAITLMHSKGSIVVANTGVK-TKDDGDAQTSTLNKVL 387

  Fly   213 -PHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGP 276
             |...:.|               |||..||..|        ....|.|.||......:.:..:..
 Worm   388 DPDFVIGD---------------LVASEVNTTS--------GITIRIWTRPEVKHSTEQSLDYAN 429

  Fly   277 KVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVA 341
            :.:...|.....:.....:|.:|||.|..|...:...:...|..:||:...:.:..|.|:|.:::
 Worm   430 QAIDAMEHILQSRLESKSLDIVAVPGFQTGNRVSPSFIVLPEEDILYNEQSNDINQKTRIARMIS 494

  Fly   342 HELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVE---NINPE--WRSMEQESLSNLLTIFRRD 401
            :.:|.||||.:...:.:...||||....::....:|   :||.:  | :.|.|.      |..||
 Worm   495 NRIAAQWFGGITNPEEFGTFWLNEALPRFLEVEALEKILDINSDDLW-TYEMEK------ILERD 552

  Fly   402 ALESSHPIS-RPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNA-- 463
            |..:|.|:. :.:...::|:|...:...:||:.||||:...:|...|...:::::.  ||::|
 Worm   553 ATATSQPLRVKNVFSSADIAEIDHEFIGKKGAAVLRMIQKSVGVNVFNKAIRSFVS--SYRSAYP 615

  Fly   464 EQDNLWESLTQA----AHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLL 524
            ..|.||:|..:|    ...:.:.|  .|:...:::|..|.|:|:::|.: ....|.:|:|||:..
 Worm   616 YDDGLWKSFEKALGGKLKGWNNEP--LDVAKFVNTWVDQIGFPLVSVEK-LDDETVELSQERFKN 677

  Fly   525 N--TQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGE--------SLPKTIQDLPGP 579
            :  |:....:|...:|            ||...|......|..|.        .||....|.
 Worm   678 DHKTKEQFKFRNAKYW------------FNWEVPLFLKSSGPVGNVSWLHEAFRLPLNTSDS--- 727

  Fly   580 DQWVIFNTQLSTLYKVNYDAQNWKLLIETL--TNGDF-ERIHVINRAQLIDDALYLAWTGEQDYE 641
               :..||..:.:|:|||:.:.|..:.:.|  ::|.. ||    .||:||.|...||.:|...:|
 Worm   728 ---IYLNTDSNGVYRVNYEEKRWNDIAKQLEKSHGKLSER----TRARLISDVFALANSGALPFE 785

  Fly   642 IAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLN-------- 698
            .|:.:..||..|...:||..|....|::...:...|..:....::.:.|...:|.::
 Worm   786 TALNVTSYLPMETATVPWLIATRIFKKLTERLEGAPIQDKLNSFIYQKIHKKFEEISSSPGEASS 850

  Fly   699 ---------GINDTFSAI-PQQDQVLLKTMVVNW---ACQYQ---VGDCVPQALAYYRNWRAEAN 747
                     .:.|..:.: |::....|..:.|..   .||:.   ..||
 Worm   851 NYLKNRLYANLLDLMAIVKPEKSNEKLNELFVEGFLAPCQFSGNFSSDC---------------- 899

  Fly   748 PDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRY-- 810
                :.||.::|..|||..::.|:|:.:|.:....:|....|||..:..:|.|.|:...|:|.
 Worm   900 ----SEVPGDLREKVYCNGVEFGNDTVFETVRELAEKEVDGAEKDLLQNSLACFRDPRALRRLIL 960

  Fly   811 --LELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLS 873
              |..|......:||.:|         ..||..:|..:.:||...:.|   ...|:....|:.::
 Worm   961 DNLNSTSTVTLLLRKMNS---------RPVGKEIATNWIIDNWSTVLK---KKFKNDPETLNAIA 1013

  Fly   874 EQVITLSDFNE---FKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMS 925
            :..|.|.:..|   .:.|:.:..:|..|:| ::.:.:|...|::.|:::..::::
 Worm  1014 DAGIILDNEREKSMIETFMEHHHKSTHGIE-SLDKKIEEATTDIYWRKQKINELN 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	118/532 (22%)
		ERAP1_C	582..910	CDD:463368	78/361 (22%)
AC3.5	NP_001256214.1	GluZincin	165..651	CDD:472708	118/531 (22%)
		beta-trefoil_FSCN-like	<685..741	CDD:483951	13/73 (18%)
		ERAP1_C	728..1056	CDD:463368	79/364 (22%)