DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and pam-1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	963	Identity:	289/963 - (30%)
Similarity:	457/963 - (47%)	Gaps:	127/963 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTL 78
            |:|...:.:.:::    :.||||...|..|::|:...|   ....|.|...|.:...|.|..:.:
Worm    64 GMAACGNPSAAVK----FERLPTFAEPTHYNVRLSPCL---NQFSFDGHATIDVTIKEATDVLKV 121

  Fly    79 HSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHD-------FYILNTCQELLAGNTYELYMP 136
            |:::|.| :|...:.|.|.        :|.::..|:|       ..:..|.|.    ...:|...
Worm   122 HAQSLLI-QSVSLITQPGD--------ASKSLETSYDDKLNILTIKLPTTMQP----QKVQLDFK 173

  Fly   137 FAADLNRQLEGYYRSSYKDPVANLT-KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKY 200
            |..:||.::.|:|||.|||  .|.| |:::.||||...||.||||||||.:||.|.|||......
Worm   174 FVGELNDKMRGFYRSQYKD--KNGTEKFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHL 236

  Fly   201 TAISNM---PEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARP 262
            ||:|||   .|..|...:..|    ..|..|..||:||||::|.:..:..:...:....|.:..|
Worm   237 TALSNMNVISETPTADGKRKA----VTFATSPKMSSYLVAFAVGELEYISAQTKSGVEMRVYTVP 297

  Fly   263 NAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAH 327
            ...:|..|:.....|.:.:|.::|.||:||||.|.||:||||.|||||||||||||||||.....
Worm   298 GKKEQGQYSLDLSVKCIDWYNEWFDIKYPLPKCDLIAIPDFSMGAMENWGLVTYREIALLVDPGV 362

  Fly   328 SSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPE---WRSMEQE 389
            :|...|.|||.||||||||.||||||||||||||||.||||:::..:.|....||   |.....:
Worm   363 TSTRQKSRVALVVAHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFKIWLHFLND 427

  Fly   390 SLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAY 454
            .|::.:.:   |||.:||||...|...:|:.|.:|.|:|.|.::|.||:..:|.|..|:.||:.|
Worm   428 ELASGMGL---DALRNSHPIEVEIDNPNELDEIYDSITYAKSNSVNRMLCYYLSEPVFQKGLRLY 489

  Fly   455 LQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVT--RDYAARTAKL 517
            |::|.|.||...:||.:|::|:        ..::..:|..||.|.|:||:.|:  :|...|...:
Worm   490 LKRFQYSNAVTQDLWTALSEAS--------GQNVNELMSGWTQQMGFPVLKVSQRQDGNNRILTV 546

  Fly   518 NQERYL-------LNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQD 575
            .|.|::       .|:|         |.||:   |.||....:.....::...|..|.   ||:.
Worm   547 EQRRFISDGGEDPKNSQ---------WQVPI---TVAVGSSPSDVKARFLLKEKQQEF---TIEG 596

  Fly   576 LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDY 640
            : .|.:||..|:..:..|:|.|..:   :|...|.:....|:.|::|..||:|...|..||....
Worm   597 V-APGEWVKLNSGTTGFYRVEYSDE---MLTAMLPDIASRRMPVLDRFGLINDLSALLNTGRVSI 657

  Fly   641 EIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFS 705
            ...:::.....:|.||:.|.:..|.:.::....|:..  |...:..|:|::.::|. .|....|:
Worm   658 AQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAREMS--EDTLKSAKQLVVKMFEQ-TGAELGFA 719

  Fly   706 AIPQQD--QVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANP-------------DEKNPVP 755
            ....:|  :::|:::|              ||    |..||...|             ::..|:.
Worm   720 EQAGEDSQKMMLRSLV--------------QA----RLARAGHQPTIDKFTQMFNDFLEKGTPIH 766

  Fly   756 INVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEA 820
            .::|...:....::|....::.|....:.:.....:|..:.|:..:.|..||.:..|..|: |..
Worm   767 PDIRLATFGVVARYGGKEGFDKLMNLRETTTFQEIERQTMVAMSQTPEESLLAQLFEYGFE-KNK 830

  Fly   821 IRKQDSMWAFQAVAFNEVGFLLAKKYFMDNV-DFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNE 884
            :|.||.::.|.......:|...|.|||.::: :|:.|:....:....|.|....|.........|
Worm   831 VRPQDQLYLFLGTGATHMGQQYAWKYFCEHIKEFLDKYGGANSSLFQRCLKFAGESFGNEKRAVE 895

  Fly   885 FKDFVNN-------SRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMSRSIQQ 930
            |:||..|       .||:   |.:.|.||:|.:..|.:..|.|...:...::|
Worm   896 FQDFFCNCNVLSDTDRQT---LARPIGQTVEAIRLNARLLESNRQIIENLLKQ 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	163/411 (40%)
		M1_APN_2	43..502	CDD:189008	182/472 (39%)
		ERAP1_C	583..908	CDD:288671	74/347 (21%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	182/474 (38%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	76/352 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020