DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and F49B2.6

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_493503.2	Gene:	F49B2.6 / 173297	WormBaseID:	WBGene00009865	Length:	1082	Species:	Caenorhabditis elegans

Alignment Length:	939	Identity:	276/939 - (29%)
Similarity:	461/939 - (49%)	Gaps:	106/939 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TTYNYY--RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQ 89
            |...:|  |||.:..|..|.|.:...|.|.| :..|.|::|||:  .:||.:.|:::||.:....
Worm   191 TNITWYSSRLPRTAEPIDYDLTLHPNLTNGE-VEASVSIRILIK--NDTKLLILNAENLEMKSFD 252

  Fly    90 ITLRQIGGEGKKE--NCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSS 152
            ||.:  |.:.|.:  .|...|.       :.....:.|..|:...|.:.::|.:...|:|.|.|:
Worm   253 ITKK--GAKVKADFVKCAVMTQ-------WAWKLAKRLHKGDHIVLTIYYSAQMKSDLQGLYFST 308

  Fly   153 YKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMP---EKETKPH 214
            :.......|| .:.|||||..||...||||||:|||.|.|.:..:..:.|.|||.   .||.| :
Worm   309 HLGTDGKKTK-SAATQFEPTFARKMLPCFDEPNFKATFQVAIIRNPHHIARSNMNILISKEYK-N 371

  Fly   215 ETLADYIWCEFQESVPMSTYLVAYSVND-FSHKPSTLPNSALFRTWARPNAIDQCDYAAQ----- 273
            ..:.|.    |::||.|||||:|.:|.| :.:......|:        ..||:...||.|
Worm   372 GLIKDV----FEKSVKMSTYLLAVAVLDGYGYIKRLTRNT--------QKAIEVRLYAPQDMLTG 424

  Fly   274 ---FG----PKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLA 331
               ||    .:.|:::|.:|.|.:||.|||.:|:.|||.||||||||||:|:.|||::...:|:.
Worm   425 QSEFGLDTTIRALEFFEDYFNISYPLDKIDLLALDDFSEGAMENWGLVTFRDSALLFNERKASVV 489

  Fly   332 DKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLT 396
            .|:.:|.::.||:|||||||||||.||.:::||||||.|:....||::.|:|..|.:....||..
Worm   490 AKEHIALIICHEIAHQWFGNLVTMDWWNEVFLNEGFANYMEYKCVEHLFPDWSIMSRFYAENLAF 554

  Fly   397 IFRRDALESSHPISRPIQMVSEISES----FDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457
            ....|...||..|.      |:..:|    ||.|:|.|.:.::.|:....|:::|::.|..||.|
Worm   555 SQEPDGFLSSRAIE------SDDDDSLLNLFDAINYHKAAAIIHMIAEMAGQKNFQNALVEYLNK 613

  Fly   458 FSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERY 522
            ::|.||...:||    :...|:.:|..:..|..:..::|.|.|||::.|.|........ ||.|:
Worm   614 YAYSNAIGVDLW----KIVEKHANLQGTVSIPDLAKAYTTQVGYPLLTVERTDEGVLVH-NQTRF 673

  Fly   523 LL-NTQVARAYRGGCWW-VPLSYTTQAVQDFNNTAPKA-WMECGKNGESLPKTIQDLPGPDQWVI 584
            |. ....|...||...| :|:||     :|..:...|. |::......:...|..|      |:|
Worm   674 LFAEGDKAEEKRGDWKWPIPISY-----RDSEHRRKKQHWIQADDKNVTWETTSND------WLI 727

  Fly   585 FNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHV----INRAQLIDDALYLAWTGEQDYEIAMR 645
            .||.....:||.||.:.::.|::.|     :|.|.    |:|:.::.|:..|:.|...:..:...
Worm   728 LNTGGVGYFKVLYDPETYRKLVKQL-----QRNHTTISPIDRSMILVDSFDLSKTSLLNISVYFD 787

  Fly   646 LIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQ 710
            |:||:::|.:.:.|....:.|:.:..::.::...:.::.:.:.||:.:||.|:.  |...|.|.|
Worm   788 LLEYVEKETDKMTWSIVGKQLRTIEALIEESDYLDIYQDFQRSLIMRLYESLDW--DEQGANPNQ 850

  Fly   711 DQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEA--NPDEKNPVPINVRSTVYCTSIKHGSDS 773
            .::.:....|  ||:.|:.||..||...|..|.:..  ||:.        ........:|.|..:
Worm   851 KRLQVDIFAV--ACRLQIKDCTKQAYQRYLQWVSSGVRNPEH--------HMIALMEGVKQGETT 905

  Fly   774 DWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEV 838
            .||.:|..||.:...:||..|:.||..:::..|:.|.|:...|.|  |:.......|...:.|:.
Worm   906 AWERIWKAYKTATSPSEKNNIIGALTSTKDASLINRLLKYCLDGK--IKANLIPRVFSYFSLNQS 968

  Fly   839 GFLLAKKYFMDNVDFIYKFYHPLTKD--MSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQ 901
            ...:..|:|..:.:   :|:..|.|.  |:..:..|:|.:.|.::..|.|:|:.:.:.:..||.:
Worm   969 TRNIVWKFFKTHFE---QFHGILGKGSLMASCVKCLAEPLSTETELEEVKEFLKSQKFAEDGLIK 1030

  Fly   902 AIQQTLEIMLTNVQWKERNYHQMSRSIQQ 930
             ::.|.|.:..|:||::.|..|:.:.|.:
Worm  1031 -MEMTYEQIELNIQWRKLNEGQLGKWISR 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	149/419 (36%)
		M1_APN_2	43..502	CDD:189008	164/480 (34%)
		ERAP1_C	583..908	CDD:288671	78/332 (23%)
F49B2.6	NP_493503.2	Peptidase_M1	199..586	CDD:279741	149/418 (36%)
		M1_APN_2	207..654	CDD:189008	164/482 (34%)
		ERAP1_C	726..1037	CDD:288671	78/333 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm14800
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.820