DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Lnpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	898	Identity:	291/898 - (32%)
Similarity:	471/898 - (52%)	Gaps:	57/898 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQIT-LRQIG 96
            ||||::.||:|.   |:|..|...:.|.|||.|.::||::|:::.|||....|  |.:| :..:.
  Rat   167 RLPTAIIPQRYE---LSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNI--SSVTFMSAVS 226

  Fly    97 GEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLT 161
            .:.|:...:.    .|.|:...:...:.||.|:.|.|.:.::|:::....|:|..:|.|. :|..
  Rat   227 SQEKQVEILE----YPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDK-SNEK 286

  Fly   162 KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQ 226
            |..:.|||||.:||.||||||||.|||.|::.:...:.:||:||||:|.:.|.|  ...|..||.
  Rat   287 KNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTE--EGLIQDEFS 349

  Fly   227 ESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFP 291
            |||.|||||||:.|.:..:....: |..|...:|.|..|||..:|.....|:|::|:.:|.|::|
  Rat   350 ESVKMSTYLVAFIVGEMRNLSQDV-NGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYP 413

  Fly   292 LPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMK 356
            |.|:|.:|:|||.|||||||||:|:||..|||..|.||:||::.|..::|||||||||||||||:
  Rat   414 LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQ 478

  Fly   357 WWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISE 421
            ||.||||||||||::....||.|..|..|.| :.|.......|:|:|.||||||..:|...:|.|
  Rat   479 WWNDLWLNEGFATFMEYFSVEKIFKELNSYE-DFLDARFKTMRKDSLNSSHPISSSVQSSEQIEE 542

  Fly   422 SFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSY 486
            .||.:||.||:::|.|:..:|.|:.|:..:..||...||...:.|:||:|..:..      .|:.
  Rat   543 MFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVT------GKTL 601

  Fly   487 DIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYL--LNTQVARAYRGGCWWVPLSYTTQAVQ 549
            |:|.:|.:||||.|:|::.|.|  ......|.|||:.  :..::..:.....|.:|:||.|.. :
  Rat   602 DVKKMMKTWTLQKGFPLVTVQR--KGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDG-R 663

  Fly   550 DFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDF 614
            :::.....:.::  |..:.:..|.|     .|||..||.::..|.|:|....|..||..|....:
  Rat   664 NYSEYRSVSLLD--KKSDVINLTEQ-----VQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPY 721

  Fly   615 ERIHVI---NRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQT 676
                |:   :||.||::...||..|:...::|..||:||:.|....|...|......:..::.:.
  Rat   722 ----VLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKL 782

  Fly   677 PDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRN 741
            ...:...|.:.::...:...:.....|....|...:  |::.::.:||.:.:.:|...|...:..
  Rat   783 GHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRE--LRSALLEFACAHSLENCTTMATKLFDG 845

  Fly   742 WRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREV-- 804
            |.|.   :....:|.:|.:||:....:  ::..|.||::.|......|||..||.||..|.:.
  Rat   846 WMAS---NGTQSLPTDVMTTVFKVGAR--TEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHK 905

  Fly   805 --WLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSR 867
              ||::..|:     .:.||.|......:.|.....|.|||..:..:|.:.:...:|..:..:..
  Rat   906 LYWLMKSSLD-----GDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQS 965

  Fly   868 LLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            :::..:....|.:..:|.::|..|..::...| :.:|:..|::..|:||..||
  Rat   966 IVAGSTHLFSTKTHLSEVQEFFENQSEATLQL-RCVQEAFEVIELNIQWMARN 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	173/398 (43%)
		M1_APN_2	43..502	CDD:189008	191/459 (42%)
		ERAP1_C	583..908	CDD:288671	71/331 (21%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	173/398 (43%)
		M1_APN_2	176..617	CDD:189008	191/460 (42%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	71/331 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349268
Domainoid	1	1.000	119	1.000	Domainoid score	I5647
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750