Protein Alignment SP1029 and Lta4h

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 612
• Identity: 143/612 - (23%)
• Similarity: 236/612 - (38%)
• Gaps: 177/612 - (28%)

  Fly    35 PTSL-RPQKYHLRI------LTLLENPEDLRFSGSVKILIEAL-ENTKNVTLHSKNLTIDESQIT 91
            |.|: |.|..|||.      .||         :|:..:.:::. ||.:::||.:|:|||::..|.
Mouse    13 PASVCRTQHLHLRCSVDFARRTL---------TGTAALTVQSQEENLRSLTLDTKDLTIEKVVIN 68

  Fly    92 LRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQ--LEGYYRSSYK 154
                |.|.|                |.|...|. ..|:..|:.:|.|...|::  :|..:.:|
Mouse    69 ----GQEVK----------------YTLGESQG-YKGSPMEISLPIALSKNQEIVIEISFETS-- 110

  Fly   155 DPVANLTKWIS------------VTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAI-SNM 206
             |.::..:|::            .:|.:....|...||.|.|..|..:...:...|:..|: |.:
Mouse   111 -PKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAI 174

  Fly   207 PEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHK---PSTLPNSALFRTWARPNAIDQC 268
            .:.|....|..:..|: .|.:.||:..||:|..|.....:   |.||       .|:....:::.
Mouse   175 RDGEAPDPEDPSRKIY-RFNQRVPIPCYLIALVVGALESRQIGPRTL-------VWSEKEQVEKS 231

  Fly   269 DYAAQF--------------GPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREI 319
              |.:|              ||.|...|:...     ||       |.|..|.|||
Mouse   232 --ANEFSETESMLKIAEDLGGPYVWGQYDLLV-----LP-------PSFPYGGMEN--------- 273

  Fly   320 ALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVA------------ 372
            ..|.....:.||..:.:::|:|||::|.|.|||||.|.|...|||||...|:.
Mouse   274 PCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKF 338

  Fly   373 ----SLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISE--SFDQISYQKG 431
                :||      .|     ..|.|.:..|     ..|||.::.:..:.::..  ::..|.|:||
Mouse   339 RHFHALG------GW-----GELQNTIKTF-----GESHPFTKLVVDLKDVDPDVAYSSIPYEKG 387

  Fly   432 STVLRMMHLFL-GEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMD-- 493
            ..:|..:...| |.|.|...|:||::||||::...|: |:|..     |.......|:.:.:|
Mouse   388 FALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDD-WKSFL-----YSHFKDKVDLLNQVDWN 446

  Fly   494 SWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPL------SYTTQAVQDFN 552
            :|....|.|.:           |.|.:..|.|..:|.:.|    ||..      |::...::|.:
Mouse   447 TWLYAPGLPPV-----------KPNYDVTLTNACIALSQR----WVTAKEEDLSSFSIADLKDLS 496

  Fly   553 NTAPKAWMECGKNGESLPKTIQDLPGP 579
            :         .:..|.|.:.:|..|.|
Mouse   497 S---------HQLNEFLAQVLQKAPLP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	122/514 (24%)
		ERAP1_C	582..910	CDD:463368
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	143/612 (23%)