DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Anpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	938	Identity:	316/938 - (33%)
Similarity:	498/938 - (53%)	Gaps:	62/938 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATA-----DSSADSIETT--------YNYYRLPTSLRPQKYHLRILT--LLENPEDLR-FSGSVK 64
            |||     .:||.:..||        :|.||||.:|.|..|.: ||.  |..|.:.|. |.|:..
Mouse    45 ATAPTLPGSTSATTATTTPAVDESKPWNQYRLPKTLIPDSYRV-ILRPYLTPNNQGLYIFQGNST 108

  Fly    65 ILIEALENTKNVTLHSKNLTI---DESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELL 126
            :.....:.|..:.:|||.|..   ...::.||.:  :|.....:..|.:....::.:::....|:
Mouse   109 VRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTL--DGTPAPNIDKTELVERTEYLVVHLQGSLV 171

  Fly   127 AGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFV 191
            .|..||:...|..:|...|.|:|||.|.:  .::.|.::.||.:.|.||.:|||||||..||.|.
Mouse   172 EGRQYEMDSQFQGELADDLAGFYRSEYME--GDVKKVVATTQMQAADARKSFPCFDEPAMKAMFN 234

  Fly   192 VTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALF 256
            :||.|.....|:|||..||:||:.........||..:..|||||:||.|::|.:..|...|....
Mouse   235 ITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQI 299

  Fly   257 RTWARPNAID--QCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREI 319
            ..||||:|||  |.|||......:|.::.|.:...:||||.||||:|||:||||||||||||||.
Mouse   300 GIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRES 364

  Fly   320 ALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWR 384
            :|::.:..||:::|:||.:|:||||||||||||||:.||.|||||||||:||..||.:...|.|.
Mouse   365 SLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWN 429

  Fly   385 SMEQESLSNLLTIFRRDALESSHPISRP---IQMVSEISESFDQISYQKGSTVLRMMHLFLGEES 446
            ..:...|:::..:...|||.||||:|.|   |:...:|.|.||.|:|.||::|:||:..||.|:.
Mouse   430 LKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDL 494

  Fly   447 FRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYA 511
            |:.||.:||..:.|.|....:|||.|.:|.::..::.....:::|||.|.||.|:|||.|.
Mouse   495 FKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVN---- 555

  Fly   512 ARTAKLNQERYLLNTQ--VARAYRGGCWWV-PLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTI 573
            ..|.:::|:.:||:::  |.|.......|: |:.:.....:|      ..|::..||..:..:|
Mouse   556 TNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQED------HYWLDVEKNQSAKFQT- 613

  Fly   574 QDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQ 638
                ..::|::.|..::..|.||||..|||.|...|.. |...|.||||||:|.|:..||.....
Mouse   614 ----SSNEWILLNINVTGYYLVNYDENNWKKLQNQLQT-DLSVIPVINRAQIIHDSFNLASAKMI 673

  Fly   639 DYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHL-----N 698
            ...:|:....:|.:|.||:||::|..:|.....:..::..:...|||:||.:.|::.:.     |
Mouse   674 PITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNN 738

  Fly   699 GINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVY 763
            .:|...:.:.|.:::    ..::.||...:.:|....:..|..|....|   .|.:..|:|||||
Mouse   739 WVNRPPTLMEQYNEI----NAISTACSSGLKECRDLVVELYSQWMKNPN---NNTIHPNLRSTVY 796

  Fly   764 CTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMW 828
            |.:|..|.:.:|.|.|.:::.:.:..|...:.:||.||::||:|.|||..|.:| :.|||||:..
Mouse   797 CNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNP-DYIRKQDTTS 860

  Fly   829 AFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDF-VNNS 892
            ...::|.|..|..|...:...|...:::.|...:...:.|:..::.:..:..:..:.:.| .:||
Mouse   861 TIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNS 925

  Fly   893 RQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            ........:|::|.||....|:.|.:.|
Mouse   926 ATGFGTGTRALEQALEKTRANIDWVKEN 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	167/408 (41%)
		M1_APN_2	43..502	CDD:189008	189/469 (40%)
		ERAP1_C	583..908	CDD:288671	90/330 (27%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		7/18 (39%)
		Metalloprotease	69..966		309/914 (34%)
		M1_APN-Q_like	84..545	CDD:341064	186/465 (40%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	618..945	CDD:403137	93/335 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845883
Domainoid	1	1.000	242	1.000	Domainoid score	I2219
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm42431
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	LDO	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.700