Protein Alignment SP1029 and Enpep

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_031960.1
• Gene: Enpep / 13809
• MGIID: 106645
• Length: 945
• Species: Mus musculus
• Alignment Length: 938
• Identity: 298/938 - (31%)
• Similarity: 496/938 - (52%)
• Gaps: 112/938 - (11%)

  Fly    19 DSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNL 83
            ||..:|.|  :..:|||..:.|..|.|.:..|:|  || |::|.|.|.:...:.|:::.||
Mouse    72 DSEDESGE--WKNFRLPDFINPVHYDLEVKALME--ED-RYTGIVTISVNLSKPTRDLWLH---- 127

  Fly    84 TIDESQIT----LRQIGGEG---------KKENCVSSTAVNPSHDFYILNTCQELLA---GNTYE 132
             |.|::||    ||:..||.         ||:            ::.::...::|.|   .:.|.
Mouse   128 -IRETKITKLPELRRPSGEQVPIRRCFEYKKQ------------EYVVIQAAEDLAATSGDSVYR 179

  Fly   133 LYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYH 197
            |.|.|...||..|.|:|:::|.:.  ...:.|:.|..||..||.:|||||||:.|:.:.:::.:.
Mouse   180 LTMEFKGWLNGSLVGFYKTTYMED--GQIRSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHP 242

  Fly   198 KKYTAISNMPEKETKPHETLADYIW--CEFQESVPMSTYLVAYSVNDF--------SHKPSTLPN 252
            |:|:|:|||||::::    :.|..|  ..|.:|||||||||.::|:.|        |.||
Mouse   243 KEYSALSNMPEEKSE----MVDDNWKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGKP----- 298

  Fly   253 SALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYR 317
               .:.:.:||..:..:|||.....|..|:|.:|.:::.|||:|:||:|||..||||||||||||
Mouse   299 ---LKVYVQPNQKETAEYAANITQAVFDYFEDYFAMEYALPKLDKIAIPDFGTGAMENWGLVTYR 360

  Fly   318 EIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPE 382
            |..|||....|:.:::|||||||||||.||||||.|||.||.|||||||||::...|||.:...:
Mouse   361 ETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKD 425

  Fly   383 WRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESF 447
            |:.:.|..|.::..:...|:|.||||:...:...:||:..||.|||.||:::|||:..::..|.|
Mouse   426 WQMLSQVLLEDVFPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKF 490

  Fly   448 RSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAA 512
            :.|.|.||:||.:.||:..:.|:||.:|:    :||    :|.:||:||.|.||||:.|     :
Mouse   491 QKGCQIYLKKFQFANAKTSDFWDSLQEAS----NLP----VKEVMDTWTSQMGYPVVTV-----S 542

  Fly   513 RTAKLNQERYLLNTQV----ARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTI 573
            ....:.|:|:||:::.    ..:..|..|.:|:.:.     |.:|:....:....|.|.:|...:
Mouse   543 GRQNITQKRFLLDSKADPSQPPSELGYTWNIPVRWA-----DNDNSRITVYNRLDKGGITLNANL 602

  Fly   574 QDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQ 638
            ..    |.::..|......|:|||:...|..:.|.|:: :..|....:|:..||||..||.....
Mouse   603 SG----DAFLKINPDHIGFYRVNYEGGTWDWIAEALSS-NHTRFSAADRSSFIDDAFALARAQLL 662

  Fly   639 DYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPD----FEFFKRYMKKLILPIYEHLNG 699
            :|:||:.|..||:.|.::|||:..   :..|..|:....|    :...:.|.:..:.|:.: |.|
Mouse   663 NYKIALNLTMYLKSEEDFLPWERV---ISSVSYIISMFEDDRELYPMIETYFQGQVKPVAD-LLG 723

  Fly   700 INDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNW-RAEANPDEKNPVPINVRSTVY 763
            ..||.|.|.:    ||:..::.:||:....:.:..|...:.:| :..|:      :|:|:|..||
Mouse   724 WQDTGSHITK----LLRASILGFACKMGDREALGNASQLFDSWLKGSAS------IPVNLRLLVY 778

  Fly   764 CTSIKH-GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSM 827
            ...::: |:::.|.:...:|:|:::|.||..:|..|...::|.||.||||:..|| ..|:.||..
Mouse   779 RYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVKLLARYLEMLKDP-NIIKTQDVF 842

  Fly   828 WAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNS 892
            ...:.:::|..|..:|..:...|.|::...:....:.:.|::: ::|...|.....:.:.|....
Mouse   843 TVIRYISYNSYGKTMAWNWIQLNWDYLVSRFTINDRYLGRIVT-IAEPFNTELQLWQMQSFFAKY 906

  Fly   893 RQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            ..:..|.:.. :|.||.:..|::|...|
Mouse   907 PNAGAGAKPR-EQVLETVKNNIEWLNVN 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	184/480 (38%)
		ERAP1_C	582..910	CDD:463368	83/333 (25%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..77		2/4 (50%)
		M1_APN-Q_like	92..531	CDD:341064	183/480 (38%)
		ERAP1_C	607..925	CDD:463368	83/335 (25%)