DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Enpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_031960.1	Gene:	Enpep / 13809	MGIID:	106645	Length:	945	Species:	Mus musculus

Alignment Length:	938	Identity:	298/938 - (31%)
Similarity:	496/938 - (52%)	Gaps:	112/938 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNL 83
            ||..:|.|  :..:|||..:.|..|.|.:..|:|  || |::|.|.|.:...:.|:::.||
Mouse    72 DSEDESGE--WKNFRLPDFINPVHYDLEVKALME--ED-RYTGIVTISVNLSKPTRDLWLH---- 127

  Fly    84 TIDESQIT----LRQIGGEG---------KKENCVSSTAVNPSHDFYILNTCQELLA---GNTYE 132
             |.|::||    ||:..||.         ||:            ::.::...::|.|   .:.|.
Mouse   128 -IRETKITKLPELRRPSGEQVPIRRCFEYKKQ------------EYVVIQAAEDLAATSGDSVYR 179

  Fly   133 LYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYH 197
            |.|.|...||..|.|:|:::|.:.  ...:.|:.|..||..||.:|||||||:.|:.:.:::.:.
Mouse   180 LTMEFKGWLNGSLVGFYKTTYMED--GQIRSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHP 242

  Fly   198 KKYTAISNMPEKETKPHETLADYIW--CEFQESVPMSTYLVAYSVNDF--------SHKPSTLPN 252
            |:|:|:|||||::::    :.|..|  ..|.:|||||||||.::|:.|        |.||
Mouse   243 KEYSALSNMPEEKSE----MVDDNWKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGKP----- 298

  Fly   253 SALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYR 317
               .:.:.:||..:..:|||.....|..|:|.:|.:::.|||:|:||:|||..||||||||||||
Mouse   299 ---LKVYVQPNQKETAEYAANITQAVFDYFEDYFAMEYALPKLDKIAIPDFGTGAMENWGLVTYR 360

  Fly   318 EIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPE 382
            |..|||....|:.:::|||||||||||.||||||.|||.||.|||||||||::...|||.:...:
Mouse   361 ETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKD 425

  Fly   383 WRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESF 447
            |:.:.|..|.::..:...|:|.||||:...:...:||:..||.|||.||:::|||:..::..|.|
Mouse   426 WQMLSQVLLEDVFPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKF 490

  Fly   448 RSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAA 512
            :.|.|.||:||.:.||:..:.|:||.:|:    :||    :|.:||:||.|.||||:.|     :
Mouse   491 QKGCQIYLKKFQFANAKTSDFWDSLQEAS----NLP----VKEVMDTWTSQMGYPVVTV-----S 542

  Fly   513 RTAKLNQERYLLNTQV----ARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTI 573
            ....:.|:|:||:::.    ..:..|..|.:|:.:.     |.:|:....:....|.|.:|...:
Mouse   543 GRQNITQKRFLLDSKADPSQPPSELGYTWNIPVRWA-----DNDNSRITVYNRLDKGGITLNANL 602

  Fly   574 QDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQ 638
            ..    |.::..|......|:|||:...|..:.|.|:: :..|....:|:..||||..||.....
Mouse   603 SG----DAFLKINPDHIGFYRVNYEGGTWDWIAEALSS-NHTRFSAADRSSFIDDAFALARAQLL 662

  Fly   639 DYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPD----FEFFKRYMKKLILPIYEHLNG 699
            :|:||:.|..||:.|.::|||:..   :..|..|:....|    :...:.|.:..:.|:.: |.|
Mouse   663 NYKIALNLTMYLKSEEDFLPWERV---ISSVSYIISMFEDDRELYPMIETYFQGQVKPVAD-LLG 723

  Fly   700 INDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNW-RAEANPDEKNPVPINVRSTVY 763
            ..||.|.|.:    ||:..::.:||:....:.:..|...:.:| :..|:      :|:|:|..||
Mouse   724 WQDTGSHITK----LLRASILGFACKMGDREALGNASQLFDSWLKGSAS------IPVNLRLLVY 778

  Fly   764 CTSIKH-GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSM 827
            ...::: |:::.|.:...:|:|:::|.||..:|..|...::|.||.||||:..|| ..|:.||..
Mouse   779 RYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVKLLARYLEMLKDP-NIIKTQDVF 842

  Fly   828 WAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNS 892
            ...:.:::|..|..:|..:...|.|::...:....:.:.|::: ::|...|.....:.:.|....
Mouse   843 TVIRYISYNSYGKTMAWNWIQLNWDYLVSRFTINDRYLGRIVT-IAEPFNTELQLWQMQSFFAKY 906

  Fly   893 RQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            ..:..|.:.. :|.||.:..|::|...|
Mouse   907 PNAGAGAKPR-EQVLETVKNNIEWLNVN 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	163/423 (39%)
		M1_APN_2	43..502	CDD:189008	187/484 (39%)
		ERAP1_C	583..908	CDD:288671	81/330 (25%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77		2/4 (50%)
		Peptidase_M1	84..474	CDD:279741	163/423 (39%)
		M1_APN_2	92..537	CDD:189008	187/486 (38%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	82/331 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810