DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Rnpepl1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_852070.3	Gene:	Rnpepl1 / 108657	MGIID:	1914170	Length:	720	Species:	Mus musculus

Alignment Length:	741	Identity:	165/741 - (22%)
Similarity:	262/741 - (35%)	Gaps:	225/741 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QKYHLRILTL-LE-NPEDLRFSGSVKILIEALENTKN---------VTLHSKNL----TIDESQI 90
            |.:.||.|.| || .||....:|.:.:.:.||.....         :.|||.:.    .:.||..
Mouse    37 QLFRLRHLQLGLELRPEARELAGCLVLELCALRPAPRALVLDAHPALRLHSVSFRRASAVSESPC 101

  Fly    91 TLR-QIGGEG------------KKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLN 142
            |.. ...|.|            :..:|..:..::|..|:           |::..:.:|.....:
Mouse   102 TFAFPAPGSGPPLPGFADAPGAESASCPLAFRLDPFTDY-----------GSSLTVTLPPEVQAH 155

  Fly   143 RQLEGYYRSSYKDPVA------NLT----KWISVTQFEPASARLAFPCFDEPDFKAPFVVT---- 193
            :..:...|.:..|..|      .||    |....||......|..|||||.|..|..:...
Mouse   156 QPFQVILRYTSTDAPAIWWLDPELTYGNAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAP 220

  Fly   194 LGYHKKYTAISNM-PEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTL-PNSALF 256
            ||.....:|..:: .|:|...|          |....|:..||||....|.  ||:.: |.|
Mouse   221 LGVQVLMSATQSVYVEEEGLYH----------FHMEHPVPAYLVALVAGDL--KPADIGPRS--- 270

  Fly   257 RTWARP-----------NAIDQCDYAAQ--FGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAM 308
            |.||.|           .|::|...||:  :||.:...|:..|     ||       |.|...||
Mouse   271 RVWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGRYDIVF-----LP-------PSFPIVAM 323

  Fly   309 ENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYV-A 372
            || ..:|:...::|.|       |:..|..|: ||:||.||||.||...|.::||:||.|||. .
Mouse   324 EN-PCLTFIISSILES-------DEFLVIDVI-HEVAHSWFGNAVTNATWEEMWLSEGLATYAQR 379

  Fly   373 SLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISE-SFDQISYQKGSTVLR 436
            .:..|.....:..:|        |.||.|||.      |.::::.|.|. |..|:..:.|.....
Mouse   380 RITTETYGAAFTCLE--------TAFRLDALH------RQMRLLGEDSPVSKLQVKLEPGVNPSH 430

  Fly   437 MMHLFL----------------GEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKS 485
            :|:||.                |.:.|...|:||::|:.:.:....:|.:|......:.:.  :|
Mouse   431 LMNLFTYEKGYCFVYYLSQLCGGPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKE--QS 493

  Fly   486 YDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTTQAVQD 550
            .|.:                         |.|..||:|
Mouse   494 VDCR-------------------------AGLEFERWL--------------------------- 506

  Fly   551 FNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWK-----LLIETLT 610
             |.|.|.........|.||.:.::.|  ...|.....:.:.......|...|:     |.::.|.
Mouse   507 -NATGPPLAEPDLSQGSSLTRPVEAL--FQLWTAEPLEQAAASASAIDISKWRTFQTALFLDRLL 568

  Fly   611 NGD---FERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRI 672
            :|.   .|.:..:::.       |.:.....:.||.:|.::.:.| .:|.|      :|.||.|
Mouse   569 DGSPLPQEVVMSLSKC-------YSSLLDSMNAEIRIRWLQIVVR-NDYYP------DLHRVRR- 618

  Fly   673 VRQTPDFEFFKRYMKKL-ILPIYEHL 697
                    |.:..|.:: .:|:||.|
Mouse   619 --------FLESQMSRMYTIPLYEDL 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	115/448 (26%)
		M1_APN_2	43..502	CDD:189008	128/533 (24%)
		ERAP1_C	583..908	CDD:288671	23/124 (19%)
Rnpepl1	NP_852070.3	M1_LTA4H	29..507	CDD:189006	134/585 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	321..325		2/3 (67%)
		Leuk-A4-hydro_C	524..668	CDD:312599	26/138 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740