DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and rnpepl1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001335117.1	Gene:	rnpepl1 / 100535895	ZFINID:	ZDB-GENE-030131-5522	Length:	692	Species:	Danio rerio

Alignment Length:	689	Identity:	154/689 - (22%)
Similarity:	247/689 - (35%)	Gaps:	200/689 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSST-AVNPSHDFYILNTCQELL 126
            |:.||  |:...::.:||.:..:.         |..|..:..:|.| .|.|..|:
Zfish    79 VQSLI--LDTHPSLLIHSVDCKVP---------GASGAPDVFLSLTYRVEPFTDY---------- 122

  Fly   127 AGNTYELYMPFAA-DLNRQLEGYYRSSYKDPVA----------NLTKWISVTQFEPASARLAFPC 180
             |::..:.:|.|. ..:|......|.:..|..|          ..|:.:..||......|..|||
Zfish   123 -GSSLNITLPAAVIRPHRAFRVTVRYTTTDGPAIWWLDAELTCGQTRPLVFTQGHSVCNRSFFPC 186

  Fly   181 FDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSH 245
            ||.|..|:.:..|:...:..|.:.:.........:.:     .:|....|:..||||....|..|
Zfish   187 FDTPAVKSTYSATVRVPEGVTVLMSASRSAYSKQDRV-----FQFSMEYPVPAYLVALVAGDLQH 246

  Fly   246 KPSTLPNSALFRTWARP-----------NAIDQCDYAAQ--FGPKVLQYYEQFFGIKFPLPKIDQ 297
             ....|.|   |.||.|           .::::....|:  |||.|...|:..|     ||
Zfish   247 -ADIGPRS---RVWAEPCILTCAVSKLGGSVERWLNVAEGLFGPYVWGRYDLVF-----LP---- 298

  Fly   298 IAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASV-VAHELAHQWFGNLVTMKWWTDL 361
               |.|...|||| ..:|:         ..||:.:.|....: |.||:||.||||.||...|.::
Zfish   299 ---PSFPIVAMEN-PCLTF---------IISSILESQEFLLIDVIHEIAHGWFGNAVTNATWEEM 350

  Fly   362 WLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQ- 425
            ||:||.|||..    ..|..|   ...|:.:.|.|:||.|||.....:......||::...|:.
Zfish   351 WLSEGLATYAQ----RRITTE---AYGEAFTCLETVFRLDALHRQMRLLGDNNPVSKLQAKFEPG 408

  Fly   426 ---------ISYQKGSTVLRMMHLFLGE-ESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYR 480
                     .:|:||...:..:....|: :.|.|.|:||::||.:.:....:|.:.....
Zfish   409 VNPSSLMNLFTYEKGFCFVSYLSQLCGDIKRFDSFLRAYIEKFRFSSVIAQDLLDFFLGF----- 468

  Fly   481 SLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTT 545
                                :|  .:.....|:...|..||:|          .|| ..||
Zfish   469 --------------------FP--ELKEGCVAQREGLEFERWL----------NGC-GPPL---- 496

  Fly   546 QAVQDFNNTAPKAWMECGKN---GESLPKTIQ---DLPG---PDQWVIFNTQLSTLYKVNYDAQN 601
                            |..:   |.:|...:|   ||.|   ||..||     ||     :|..:
Zfish   497 ----------------CEPDLSAGRTLTGPVQHLCDLWGNDAPDTQVI-----ST-----FDLSS 535

  Fly   602 WKLLIETLTNGDFERIHVINRAQLIDDAL------YLAWTGEQDYEIAMRLIEYLQREREYLPWK 660
            |. ..:|:...|    .:::|:.|..:.:      |.|...:.:.|:.:|.::.:.|       .
Zfish   536 WS-TFQTVLFLD----RLLDRSPLSQEVMSLLSSCYAALLDDMNAEVQIRWLQIVVR-------N 588

  Fly   661 SAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNG 699
            |.:.:|.||...:.        |...:...:|:||.|.|
Zfish   589 SFYPDLPRVRSFLH--------KHTSRMYTVPLYEDLCG 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	99/403 (25%)
		M1_APN_2	43..502	CDD:189008	110/475 (23%)
		ERAP1_C	583..908	CDD:288671	25/123 (20%)
rnpepl1	NP_001335117.1	M1_LTA4H	36..490	CDD:189006	116/507 (23%)
rnpepl1	NP_001335117.1	Leuk-A4-hydro_C	507..649	CDD:312599	32/143 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740