DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and enpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	933	Identity:	300/933 - (32%)
Similarity:	493/933 - (52%)	Gaps:	99/933 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNL 83
            ||:.|     :..:||||.:.|..|::.:..::|..   .::|:|.|.:...:.:|::.||.:..
Frog    90 DSNGD-----WKEFRLPTYINPVHYNVELHPVMEQD---TYNGTVSIWLRLSKTSKHLWLHLRET 146

  Fly    84 TIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGN-------TYELYMPFAADL 141
            .| ..|:||.:...:...:.|....   |:.  |::...|::|..|       ||.|.:.||..|
Frog   147 KI-IGQLTLTRGSQQIPIQQCFQYI---PNE--YLVLEAQQVLDPNSPTDENDTYCLTLQFAGRL 205

  Fly   142 NRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNM 206
            :..|.|:||::|::  ..:||.|:....||..||.:|||||||:.||.:.:::.:.::|.|||||
Frog   206 DGSLVGFYRTTYQE--NGVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHREEYDAISNM 268

  Fly   207 PEKETKP-----HETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAID 266
            |.:|:..     ..||       |::|||||||||.::|:.|.:...........|.:.:|....
Frog   269 PVQESVALGNGWKRTL-------FEKSVPMSTYLVCFAVHQFKYVERLSKRGVPLRIYVQPLQNA 326

  Fly   267 QCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLA 331
            ..:|||.....|..::|::|.:.:.|||:||||:|||..||||||||:||||..|||....|:..
Frog   327 TAEYAANTTKIVFDFFEEYFNMPYSLPKLDQIAIPDFGTGAMENWGLITYRETNLLYDPNESATV 391

  Fly   332 DKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLT 396
            :|||||:|:||||.||||||:|||.||.|||||||||::....||:...|.|..::|..:.:||.
Frog   392 NKQRVAAVIAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQILIDDLLP 456

  Fly   397 IFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYK 461
            :.|.|||.|||||...:...:||:..||.|||.||:::|||:..::..|:|:.|.|.||:.:.:|
Frog   457 VMRDDALLSSHPIIVTVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQDYLKDYVFK 521

  Fly   462 NAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNT 526
            ||:.|:.|.||.:|:.|        .:|.:||:||.|.||||:||.   :..|.|  |.|:||:.
Frog   522 NAKTDDFWNSLAKASGK--------PVKEVMDTWTRQMGYPVLNVE---SLNTVK--QTRFLLDP 573

  Fly   527 QVARAYR-----GGCWWVPLS-YTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLP---GPDQW 582
            . |.|..     ...|.:|:: |.|....|:|....|          |:|..:...|   ..|.:
Frog   574 N-ANALEPPSEFNYMWNIPVTFYATNNSVDYNLLYNK----------SIPAGLSLTPFNDATDGF 627

  Fly   583 VIFNTQLSTLYKVNYDAQNWKLLI-------ETLTNGDFERIHVINRAQLIDDALYLAWTGEQDY 640
            :..||:....::|||:...|..|.       ||.|:.|        ||.|||||..||...:.||
Frog   628 LKINTRHLGFFRVNYELSTWNQLSALLEANHETFTDAD--------RAGLIDDAFALARAEKLDY 684

  Fly   641 EIAMRLIEYLQREREYLPWKSAFENLKRVGRIVR-QTPDFEFFKRYMKKLILPIYEHLNGINDTF 704
            .|::.:.:||::|..||.|..|..:|..:..::. ....:..|:.|::|.:.||.:. :|..||.
Frog   685 NISLDITKYLEKETNYLTWTRAISSLAYLSDMLEDDNTIYPKFQEYLRKQVKPITQK-HGWEDTG 748

  Fly   705 SAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKH 769
            |.|.:    ||:..|:..:|:....|.:.:|...:|:|....:      :|:|:|..||...::.
Frog   749 SDIDK----LLRASVLALSCKMGDPDALNEASRLFRDWIGGKS------IPVNLRQLVYRYGMQQ 803

  Fly   770 -GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAV 833
             |:...|.:::.:|..:::|.||..:|..|..:..:.|:.|||:|.:: ...|:.||::.....:
Frog   804 SGNQESWNYMFQQYLTTSLAQEKEKLLQGLASANNIELIDRYLKLIYN-TSLIKSQDALNVIYYI 867

  Fly   834 A-FNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLK 897
            : :::.|..:|..:...|.|::...|:...:::.|:::.:|....|.:...:.::|......:..
Frog   868 SVYSQYGKQMAWDWVRINWDYLVDRYNINDRNLGRIVTRISGTFNTATQLWQMENFFEKYPNAGA 932

  Fly   898 GLEQAIQQTLEIMLTNVQWKERN 920
            | |...:|.||.:..|::|...|
Frog   933 G-EIPRKQALETVRNNIEWVAAN 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	159/409 (39%)
		M1_APN_2	43..502	CDD:189008	181/470 (39%)
		ERAP1_C	583..908	CDD:288671	82/334 (25%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	178/467 (38%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	84/339 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920