DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and anpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	939	Identity:	322/939 - (34%)
Similarity:	497/939 - (52%)	Gaps:	74/939 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATADSSADSIETT--YNYYRLPTSLRPQKYHLRILT-LLENPEDLR-FSGSVKILIEALENTKNV 76
            |||.::|.:.::.  :|.||||.:|.|..|.:.:.. |::|.:.|. |.|.........:.|..:
Frog    65 ATATATATTAQSNDPWNKYRLPKTLSPVHYDVELQPFLVKNADGLYVFRGKSTAFFICNDATDLI 129

  Fly    77 TLHSKNLT---IDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFA 138
            .:||..|.   .:.....|:    :|..:..:.||.......|.::.....|:.|..|.||..|.
Frog   130 IIHSNKLNHTKFNSFDAKLQ----DGATDVALKSTFFQKDKQFLVVQAAANLVPGKQYGLYTEFV 190

  Fly   139 ADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAI 203
            .:|...|.|:|||.|.:.  .:||.|:.||.:...||.||||||||..||.|.:||.|.:.|.|:
Frog   191 GELADDLAGFYRSEYLED--GVTKIIATTQMQAPDARKAFPCFDEPAMKATFNITLKYRQPYKAM 253

  Fly   204 SNMPEKETKPHETLAD----YIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSAL---FRTWAR 261
            |||.|.:   ..|:.:    :...:|.::..||:||||:.|::|.....  |.:|.   .:.|.|
Frog   254 SNMREID---RSTVTEDGQQWTVSKFDKTPKMSSYLVAFIVSEFEAVGD--PGNATVTGVQIWGR 313

  Fly   262 PNAI---DQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLY 323
            ..||   :|.:||......:|.::.:::...:||||.||:|:||||||||||||||||||.|||:
Frog   314 KKAIQDENQGEYALSVTKPILDFFAEYYRTPYPLPKSDQVALPDFSAGAMENWGLVTYRETALLF 378

  Fly   324 SAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQ 388
            ....||:.:|:||.:|:||||||||||||||::||.|||||||||:||..||.:...|.|...:.
Frog   379 DDQVSSIGNKERVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADKAEPNWNIKDL 443

  Fly   389 ESLSNLLTIFRRDALESSHPISR---PIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSG 450
            ..|:::..:...|||.||||::.   .:...||||..||.|:|.||::|:||:..||.|..|..|
Frog   444 IVLNDVHRVMAVDALASSHPLTSREDEVNSPSEISALFDSIAYSKGASVIRMLSEFLTEPLFVDG 508

  Fly   451 LQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTA 515
            |.:||:.|.|.|....:||..|..|.:...::.....||.|||:|.||.|:||:.:  |.|  |.
Frog   509 LASYLKGFEYSNTVYSDLWTHLQWAVNNQTAVKLPLPIKDIMDTWVLQMGFPVVKI--DTA--TG 569

  Fly   516 KLNQERYLL--NTQVARA----YRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQ 574
            .:.|:.:||  ::.|.|.    |:   |.||:||...:.:|      ..|::    .||  :|::
Frog   570 VVTQKHFLLDPDSVVTRPSPFDYK---WKVPISYKISSKED------NIWLQ----NES--ETVE 619

  Fly   575 D--LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGE 637
            |  :.|.| |::.|..::..|:||||..||..|:..|.. ..:.|.||||||:||||..||...:
Frog   620 DFKITGND-WLLVNLNVTGYYRVNYDDNNWSRLLNQLQT-SHQAIPVINRAQIIDDAFNLARAKQ 682

  Fly   638 QDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHL----- 697
            .....|:...:|:..:|||:||::|...|....::..:|..|...|:|||..:.|::|:.
Frog   683 ITTIQALDTTKYISADREYMPWQAALSGLSYFTQMFDRTEVFGPMKKYMKMQVNPLFEYFKQETG 747

  Fly   698 NGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTV 762
            |..|...|...|..::    ..::.||.|.:.||:..|...:..|.  |.|.:.|..| |:|:.|
Frog   748 NWTNRPVSLTDQYCEI----NTLSTACSYDIEDCLKFASELFSQWM--ATPQQNNIHP-NLRTNV 805

  Fly   763 YCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSM 827
            |||::..|.:.:|.|:|.|::.:::|.|:..:..||.||:|.|:|.|:||.:.|| ..||:||::
Frog   806 YCTAVAQGGEQEWNFVWDRFQLTDIAQEQDKLRAALACSKEPWILNRFLEYSLDP-TMIRRQDAV 869

  Fly   828 WAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDF-VNN 891
            ....:|..|.:|..||..:.......:|..:...:.....|:..::.:..|..:..:...| .:|
Frog   870 STISSVVNNPIGQSLAWDFVRAKWKTLYSMFGESSFSFGNLIERVTRRFSTEFELQQLLQFKADN 934

  Fly   892 SRQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            .........||::|.:|....|:.|..:|
Frog   935 QNPGFGTASQALEQAIEKTKANINWVNQN 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	161/415 (39%)
		M1_APN_2	43..502	CDD:189008	185/476 (39%)
		ERAP1_C	583..908	CDD:288671	97/330 (29%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	182/473 (38%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	99/335 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110