DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and erap2

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	1005	Identity:	320/1005 - (31%)
Similarity:	466/1005 - (46%)	Gaps:	156/1005 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVAAL------------GLGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDL 57
            |||:.:|            |..|||     |.:...::..|||..:.|..|||.|   ..|...|
Zfish     9 LLFLESLCYVQSSESNSPTGDNLAT-----DGLPFPWSKVRLPNYIVPVHYHLLI---HPNLTTL 65

  Fly    58 RFSGSVKILIEALENTKNVTLHSKNLTI------DESQITLRQIGGEGKKENCVSSTAVNPSHDF 116
            .|:|||||.|:...||..|.||||||.|      ||.:..|.:         ...|....|.|:.
Zfish    66 SFTGSVKIEIDVKNNTNWVVLHSKNLKIYTATVLDEHEAHLSE---------KTLSVLEYPLHEQ 121

  Fly   117 YILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCF 181
            ..:.:.:.|.:|..|.||:.|.|.|:....|:|:|:|:.. :..|:.::.|.|||.|||:|.|||
Zfish   122 IAIFSPKILTSGEKYFLYLEFGAPLSDGFHGFYKSTYRTK-SGETRVLASTHFEPTSARMALPCF 185

  Fly   182 DEPDFKAPFVVTLGYHKKYTAISNMPEKETK--PHETLADYIWCEFQESVPMSTYLVAYSVNDFS 244
            |||.|||.:.|.:.....:.|:||||.::|.  .:....|:    |:.||.||:||:|:.:.||.
Zfish   186 DEPVFKANYTVRIRRGPSHIALSNMPLEQTVEISNGLFEDH----FEASVKMSSYLLAFIICDFK 246

  Fly   245 HKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAME 309
            ..............:|.|....|..||.:...::|::|||:|.|.:||||:|.||:|||.:||||
Zfish   247 SVSGLTATGINISIYAVPEKWHQTQYALEAALRLLEFYEQYFNILYPLPKLDLIAIPDFESGAME 311

  Fly   310 NWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASL 374
            ||||.||||.:|||....||.:||..|..|:.||||||||||||||.||.|:|||||||.|:.|:
Zfish   312 NWGLTTYRETSLLYDPDISSASDKLWVTMVIGHELAHQWFGNLVTMDWWNDIWLNEGFARYMESV 376

  Fly   375 GVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMH 439
            .||.:.||.: :|...|........||:|.||.|||...:..::|.|.||.:||:||:.:|.|:.
Zfish   377 SVEAVYPELK-VEDHFLDTCFGAIGRDSLNSSRPISSLAESPTQIKEMFDTVSYEKGACILHMLR 440

  Fly   440 LFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAA-------------------HKYRSLPKS 485
            .||.:|.|:||:..||::|||.||..::||:||.:..                   :.||...:.
Zfish   441 HFLTDEGFQSGIIRYLRRFSYCNARNEDLWDSLIKTCSEEDFAAGEYCYSSAQATKNAYRFAGEH 505

  Fly   486 YDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLL-----NTQVARAYRGGCWWVPLSYTT 545
            .|:|.:|::||||.|.|::.|.|.  .|...:.|||:|.     :........|..|.:||:|.|
Zfish   506 VDLKKMMNTWTLQKGIPLVTVKRQ--GRKLHIGQERFLKIVLPDDPSWHSLQDGYLWHIPLTYKT 568

  Fly   546 QAVQDFNNTAPKAWMECGKNGESLPKTIQD-------LPGPDQWVIFNTQLSTLYKVNYDAQNWK 603
                              .:.:...|.|.|       |.....||..||.::..|.|:||.:.|.
Zfish   569 ------------------SHSDHEVKHILDKKSDVLLLDEHVDWVKLNTDMNGYYIVHYDEEGWN 615

  Fly   604 LLIETL----TNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFE 664
            .|.|.|    |...|:     :||.||.:|..|...|....:.|:.||.||:.|...:|......
Zfish   616 ALTELLKVNHTALSFK-----DRASLIHNAFQLVTAGRLSLDRALDLIAYLKSETHNVPLLQGLG 675

  Fly   665 NLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNG-----INDTFSAIPQQDQVL-----LKTMV 719
            .|:            .|:|...|:.|..:..:|..     ..|........|..:     |:..|
Zfish   676 YLQ------------SFYKLIEKRKIADVTHNLKTYILQYFKDVIDKQSWSDDGMVSDRRLREDV 728

  Fly   720 VNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKK 784
            ::.||......|:.:|...:.:|   ...:....:|.:|..|||....:  .||.|.:|..:|..
Zfish   729 LSLACDLDYPPCLEKAERLFVSW---VKSNGTISLPTDVSETVYMVGAQ--DDSGWVYLLRQYGV 788

  Fly   785 SNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMD 849
            |....||...|:||..|::...|.|.|:|..: ...|:.|:.......||.|.||..||
Zfish   789 SMCETEKSKFLSALTSSKDSEKLSRLLQLGME-GTVIKTQNLPSLIYMVARNPVGHFLA------ 846

  Fly   850 NVDFIYKFYHPLTKDMSRLLSPLSE------------QVITLSDFNEFKDFVNNSRQSLKGLEQA 902
             .||:.|.::.|.:..     ||..            |..:..:..|.:.|..:.::.:..| :.
Zfish   847 -WDFVKKHWNELVEKF-----PLGSFGIREIIVGTVTQFSSTEELREVESFFKSIQEQVSQL-RI 904

  Fly   903 IQQTLEIMLTNVQWKERNYHQMSRSIQQLL 932
            ||...|.:..|:.|.:||...|...:|:.|
Zfish   905 IQVATENVEKNIVWLKRNLETMRTWLQRRL 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	169/405 (42%)
		M1_APN_2	43..502	CDD:189008	196/485 (40%)
		ERAP1_C	583..908	CDD:288671	84/350 (24%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	169/405 (42%)
		M1_APN_2	52..522	CDD:189008	196/487 (40%)
		ERAP1_C	595..911	CDD:288671	84/351 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850