DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and trhde.1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_001345457.3	Gene:	trhde.1 / 100006808	ZFINID:	ZDB-GENE-170406-2	Length:	994	Species:	Danio rerio

Alignment Length:	969	Identity:	311/969 - (32%)
Similarity:	503/969 - (51%)	Gaps:	98/969 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AALGLGLATADSSADSI-----------------ETTYNYYRLPTSLRPQKYHLRILTLLENPED 56
            ||...|...|:.|::|.                 :..:.:.|||.:|||:.|.||:...:||
Zfish    68 AAESSGALAANGSSNSKWKQSRDGNISHRDSEDGQQPWRHLRLPATLRPRHYDLRLTVHMEN--- 129

  Fly    57 LRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDF----- 116
            ..|||.|.|..|.:.:||.:.|||..|.:|:..:.     .:.||     :.|:.....|
Zfish   130 FSFSGEVNIEFECVNSTKLIVLHSDRLELDKVLVF-----SDSKK-----AGAMRIQRRFHYQPK 184

  Fly   117 --YILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFP 179
              |::...:|:....||::.:.|.|.:..:|.|::||||.  :....::::||||.|..||.|||
Zfish   185 QVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSSYM--LNGERRFLAVTQFSPTHARKAFP 247

  Fly   180 CFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFS 244
            |||||.:||.|.|:|.:...|.::||||.:.|...|.  .::...|..:..||||.:|::|.:|:
Zfish   248 CFDEPIYKATFRVSLKHESSYQSLSNMPVEATTSDED--GWVTNHFSRTPRMSTYYLAWAVCNFT 310

  Fly   245 HKPSTLPNSALFRTWARPNAID--QCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGA 307
            :|.:...|..|.|.:|||:||.  ..|||.:...::||:|:.:|.:|:.|||:|.:|||.....|
Zfish   311 YKEAVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFKVKYSLPKLDLLAVPKHPYSA 375

  Fly   308 MENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVA 372
            ||||||..:.|..:|.....||.:.:..:..||.||:.|||||:|||..||.|:||.||||.|..
Zfish   376 MENWGLSVFVEQKILLDPEVSSFSYQMELTVVVVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFE 440

  Fly   373 SLGVENINPEWRSMEQESLSNLL-TIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLR 436
            .:|.:.:.|:|...:|..|:::| .:...|.|.||||||:.:...::|...||.|:|:||:.::|
Zfish   441 YIGADFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPISQQVFEATDIDRVFDWIAYKKGAALIR 505

  Fly   437 MMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGY 501
            |:...:|:..|:..|..||....|.||.:|:||..|::|..:.   .|..:|..:||.||||.||
Zfish   506 MLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSEAMQRE---GKDINITQVMDRWTLQMGY 567

  Fly   502 PVINVTR-DYAARTAKLNQERYLLNTQVA--------RAYRGGCWWVPLSYTTQAVQDFNNTAPK 557
            ||:.::: |....:..::||.::.:|...        ::::   |.:||   |.||.:.::.:.:
Zfish   568 PVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNKSFQ---WQIPL---TLAVGNASHISTE 626

  Fly   558 A--WM----ECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFER 616
            .  |:    |..:.|..:.:|         |::.|...:..::||||..||||||:.|.:.. ..
Zfish   627 TIIWVTNKSEAHRVGHMVGET---------WLLGNINQTGYFRVNYDLHNWKLLIQQLMSNP-TI 681

  Fly   617 IHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEF 681
            |.|.|||.||||...||..|.....:.:::|.||.:|.|:|||.:|...|.::.:::.:|.|...
Zfish   682 ISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQEPEFLPWHAASRALYQLDKLLDRTLDHSL 746

  Fly   682 FKRYMKKLILPIYEHL----NGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNW 742
            |..|:.:.:.|.|..|    ...:.:|.....|.:.|.:. |:..||.:....|..||::...:|
Zfish   747 FSDYVLRQVEPKYHKLGWPATSPDGSFMHSAYQTEELQRE-VIMLACSFGNKHCHRQAVSLISDW 810

  Fly   743 RAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLL 807
            .:    ..||.:|.|||..||||.:....:..|||:|.::..|...:||:.:|.||.||..::||
Zfish   811 IS----SNKNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTAVSEKKVLLEALTCSDNIFLL 871

  Fly   808 QRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPL 872
            .|.|.|:. ..:.:..||.:.....||.|.:|..||.:||.:..|.:...|.......|:|:|.:
Zfish   872 NRLLNLSL-TSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREKWDILNSRYGEALFMNSKLISGV 935

  Fly   873 SEQVITLSDFNEFKDFVNNSRQSLKGLEQ--AIQQTLEIMLTNVQWK---ERNYHQMSR 926
            :|.:.|.::.||.|:|:..|     |.|.  |..:.:||:..||:|.   :..::|..|
Zfish   936 TEFLNTEAELNELKEFILTS-----GGESAPAFARAVEIVQANVKWHILFQEQFYQWLR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	151/407 (37%)
		M1_APN_2	43..502	CDD:189008	171/468 (37%)
		ERAP1_C	583..908	CDD:288671	103/330 (31%)
trhde.1	XP_001345457.3	Peptidase_M1	109..500	CDD:279741	151/407 (37%)
		M1_APN_2	118..568	CDD:189008	171/469 (36%)
		ERAP1_C	649..968	CDD:288671	103/330 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840