DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aplip1 and Dab2

DIOPT Version :9

Sequence 1:	NP_728573.1	Gene:	Aplip1 / 53472	FlyBaseID:	FBgn0040281	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_077073.1	Gene:	Dab2 / 79128	RGDID:	621007	Length:	768	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	77/348 - (22%)
Similarity:	110/348 - (31%)	Gaps:	140/348 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LEDSHSSKSDGD---------------GSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGS 94
            :|:::.::.:|.               |.||.|..|.:...|.:.  ...|..|.|.|.|:|:
  Rat   182 VEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLN--NPTESRDILLVDLNSE-- 242

  Fly    95 LDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAP---------------VTIG-------- 136
            :|||.  ||.|.:|         ||   |:|:...|.|               ..:.
  Rat   243 IDTNQ--NSLRENP---------FL---TNGVTSCSLPRPKPQASFLPESAFSANLNFFPTPNPD 293

  Fly   137 -------ASTDLLAPN-----TAATRRRRKLPEI--PKNKKSSILHLLGGSN--FGSLADEFRNG 185
                   |..|..||:     |:|.:::.....:  |::|..     |.|..  ||...|:..|.
  Rat   294 PFRDDPFAQPDQSAPSSFHSLTSADQKKANPGSLSTPQSKGP-----LNGDTDYFGQQFDQISNR 353

  Fly   186 GG-----GGIPP--------AVRS------GQQRSF----------------LSLKCGYLMDEDS 215
            .|     ||..|        |||:      .:|..|                ||:..|...|.:|
  Rat   354 TGKQEAQGGPWPYPSSQTQQAVRTQNGVSEKEQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLES 418

  Fly   216 SPDSERMQSLGDVDSGHST---------AHSPND------FKSMSPQITSP-----VSQSPF--- 257
            |..|....|:..:....||         ..|.||      |.|..|...||     |.|:.|
  Rat   419 SVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFASEPPGQMSPTGQPAVPQANFMDL 483

  Fly   258 -----PPPFGGVPFGQLEMLEAT 275
                 |.|.|..|...|..:..|
  Rat   484 FKTSAPAPMGSGPLVGLGTVPVT 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	1/1 (100%)
Aplip1	NP_728573.1	PTB_JIP	343..490	CDD:269923
Dab2	NP_077073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PTB_Dab	35..171	CDD:269926
		Required for localization to clathrin-coated pits. /evidence=ECO:0000250	230..447		52/237 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..449		33/168 (20%)
		DPF 1	293..295		0/1 (0%)
		DPF 2	298..300		0/1 (0%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000250	601..731
		Required for interaction with CSK	619..627
		Required for interaction with MYO6. /evidence=ECO:0000250	649..768
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..682
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000269\|PubMed:12473651	663..671
		Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250	708..724
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930