DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aplip1 and mapk8ip2

DIOPT Version :9

Sequence 1:	NP_728573.1	Gene:	Aplip1 / 53472	FlyBaseID:	FBgn0040281	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_685086.6	Gene:	mapk8ip2 / 561262	ZFINID:	ZDB-GENE-070705-326	Length:	1242	Species:	Danio rerio

Alignment Length:	511	Identity:	156/511 - (30%)
Similarity:	242/511 - (47%)	Gaps:	110/511 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PNDDL------EDSHSSKSDGDGSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSD-GSLDTN 98
            ||:||      |....|.|:...||:::|     .|.|:.|:....:.: :|.:|:.| .:..||
Zfish   781 PNNDLMMERMKELDSPSLSESIISDKDEG-----RETKVDQLTLQRITE-VKNSLTLDLPTAQTN 839

  Fly    99 DSFNSHRHHPLNHQDAIGGFLGMDTSGL--GGNSAPVTIGAST--DLLAPNTAATRR-RRKLPEI 158
            ..| |..:...|.:|.      .|||..  ..:..|...|..|  |...|...:.|. |.:..:.
Zfish   840 HCF-SLTYSTDNDEDE------QDTSPFLDDLHKIPSPYGNETYLDSSPPIDESVRELRNRTSDR 897

  Fly   159 PKN--------------KKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCGY 209
            |.:              .:::.|.|:......|:..|..:|                 ||..|
Zfish   898 PIDDSLAYDSMKYTLVVDENTTLELVSLKRCTSVLSEDSDG-----------------LSTIC-- 943

  Fly   210 LMDEDSSPDSERMQSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQSPFPPPFGGV---------- 264
              |:|.:.:.:.:...|.:..|    ..||...|.|.:.:||.:..||...|..|
Zfish   944 --DDDVADEDDDIYGRGQMVRG----MRPNLLLSSSEEDSSPEADLPFSKKFLNVFVNGTSRSSS 1002

  Fly   265 --PFGQL------EMLEATHRGLHKFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGI 321
              .||..      |..:.|||.:.:|:|||.||:||::.|.::|::|.:|.|..|.|:|||.:||
Zfish  1003 TESFGLFSCTINGEERDQTHRAVFRFIPRHADELELDVDDPLFVEEEEDDYWYRGYNMRTGARGI 1067

  Fly   322 FPSAYAVDLDYNEFDPTVQLVKK-----ERYLLGYLGSVETLAHKGTGVVCQAVRKIV-----GE 376
            ||:.||.::.....|  :..:|:     |.:.:.:|||||...|:|.|::|.|::||.     ..
Zfish  1068 FPAYYAHEVVGQTKD--LMTMKRNPAWMESFRVQFLGSVEVPYHQGNGILCAAMQKIAMARKRTV 1130

  Fly   377 YGNSPTGQTCILEVSDQGLRMV-------DRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHR 434
            :.:.|:  .|.||:|.||:::|       |.||    :.|:  | .:|:.:||:|||..||:::.
Zfish  1131 HLHPPS--ICELEISLQGVKLVMSLDDEYDLSG----EFDR--C-SHFFQMKNISFCGCHPKNNC 1186

  Fly   435 FIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE 490
            :.|||||||.:.|||||||...:|.|.|||.||||||.:||:.:|.|.|.||||:|
Zfish  1187 YFGFITKHPMLNRFACHVFVSQDSMRHVAECVGRAFQEYYQEHLEYACPTEDIYLE 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	27/53 (51%)
Aplip1	NP_728573.1	PTB_JIP	343..490	CDD:269923	69/163 (42%)
mapk8ip2	XP_685086.6	SH3_JIP2	1021..1075	CDD:212875	27/53 (51%)
mapk8ip2	XP_685086.6	PTB_JIP	1092..1242	CDD:269923	68/158 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573994
Domainoid	1	1.000	110	1.000	Domainoid score	I6256
eggNOG	1	0.900	-	-		E1_KOG3775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003016
OrthoInspector	1	1.000	-	-		otm24892
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3474
SonicParanoid	1	1.000	-	-		X2453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.830