Protein Alignment Aplip1 and MAPK8IP2

DIOPT Version :9

• Sequence 1: NP_728573.1
• Gene: Aplip1 / 53472
• FlyBaseID: FBgn0040281
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: XP_011528981.1
• Gene: MAPK8IP2 / 23542
• HGNCID: 6883
• Length: 825
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 122/358 - (34%)
• Similarity: 181/358 - (50%)
• Gaps: 75/358 - (20%)

  Fly   185 GGGGGIPPAVRSGQ----------------QRSFLSL-KC---GYLMDEDSSPDSERMQS----L 225
            ||.|..|.|.|...                |...:|| :|   |:..:|||..::...::    |
Human   491 GGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSGGEASEEEAGAALL 555

  Fly   226 GDVD-SGHSTAHSP---------NDFKSMSPQITSPVSQSPFPPPFGGVPFGQLEMLEATHRGLH 280
            |... ||.::..||         |.|.:.:.:.:|..|...|.....|      |..|.|||.:.
Human   556 GGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNG------EEREQTHRAVF 614

  Fly   281 KFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKK- 344
            :|:|||.||:||::.|.:.|:.|.:|.|..|.|:|||.:|:||:.||..:.    .|...|:..
Human   615 RFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVP----GPAKDLLGSK 675

  Fly   345 ------ERYLLGYLGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQ----------TCILEVSDQ 393
                  ||:.:.:|||||...|:|.|::|.|::||.       |.:          :|.||:|.:
Human   676 RSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIA-------TARKLTVHLRPPASCDLEISLR 733

  Fly   394 GLRM-VDRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSE 457
            |::: :...||...:     | .:|:.:||:|||..|||:..:.|||||||.:.|||||||...|
Human   734 GVKLSLSGGGPEFQR-----C-SHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQE 792

  Fly   458 STRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE 490
            |.||||::|||||..:||:.:..|.|.||||:|
Human   793 SMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	26/53 (49%)
		PTB_JIP	343..490	CDD:269923	65/164 (40%)
MAPK8IP2	XP_011528981.1	SH3_JIP2	609..663	CDD:212875	26/53 (49%)
		PTB_JIP	680..825	CDD:269923	65/157 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141118
Domainoid	1	1.000	123	1.000	Domainoid score	I5599
eggNOG	1	0.900	-	-		E1_KOG3775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003016
OrthoInspector	1	1.000	-	-		otm40755
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11232
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2453
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800