DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aplip1 and FAM43A

DIOPT Version :9

Sequence 1:	NP_728573.1	Gene:	Aplip1 / 53472	FlyBaseID:	FBgn0040281	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_710157.2	Gene:	FAM43A / 131583	HGNCID:	26888	Length:	423	Species:	Homo sapiens

Alignment Length:	183	Identity:	43/183 - (23%)
Similarity:	65/183 - (35%)	Gaps:	48/183 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 RQGIFPSAYAVDLDYNEF-------------------------------DPTVQLVKKERYLLGY 351
            ||...|..|||.|.|:..                               |||        |.:.|
Human    18 RQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPT--------YTVLY 74

  Fly   352 LGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPCIDY 416
            ||:..|:..:|.|....||.||..:......|....|.||.||:|||..    :.:..::|  .:
Human    75 LGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHA----EERALRRP--GH 133

  Fly   417 FYSLKNVSFCAFHPRDHRFIGFITKHPTVQR---FACHVFKGSESTRPVAEAV 466
            .|.|..|::|....|..:...::.:|....:   ..||....|:..:..|.|:
Human   134 LYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMAL 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	5/10 (50%)
Aplip1	NP_728573.1	PTB_JIP	343..490	CDD:269923	32/127 (25%)
FAM43A	NP_710157.2	PID_2	69..256	CDD:317162	33/132 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840