DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aplip1 and Dab2

DIOPT Version :9

Sequence 1:	NP_728573.1	Gene:	Aplip1 / 53472	FlyBaseID:	FBgn0040281	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_075607.2	Gene:	Dab2 / 13132	MGIID:	109175	Length:	766	Species:	Mus musculus

Alignment Length:	261	Identity:	58/261 - (22%)
Similarity:	95/261 - (36%)	Gaps:	87/261 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LEDSHSSKSDGD---------------GSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGS 94
            :|:::.::.:|.               |.||.|..|.:...|.:....:.:  |.|.|.|:|:
Mouse   182 VEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNSPTESK--DILLVDLNSE-- 242

  Fly    95 LDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAPVTIGASTDLLAPNTAATRRRRKLPEIP 159
            :|||.  ||.|.:|         ||   |:|:...|.|                 |.:.:...:|
Mouse   243 IDTNQ--NSLRENP---------FL---TNGVTSCSLP-----------------RPKPQASFLP 276

  Fly   160 KNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQ--RSFLSLKCGYLMDEDSSPDSERM 222
            :|..|:.|:.....|    .|.||:      .|..:..|.  .||.||         :|||.::.
Mouse   277 ENAFSANLNFFPTPN----PDPFRD------DPFAQPDQSAPSSFDSL---------TSPDQKKA 322

  Fly   223 --------QSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQ-SPFPPPFGGVPFGQLEMLEATHRG 278
                    ||.|.::.  .|.:....|..:|.:...|.:| .|:|     .|..|.:....|..|
Mouse   323 SLSSSSTPQSKGPLNG--DTDYFGQQFDQLSNRTGKPEAQGGPWP-----YPSSQTQQAVRTQNG 380

  Fly   279 L 279
            :
Mouse   381 V 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	2/5 (40%)
Aplip1	NP_728573.1	PTB_JIP	343..490	CDD:269923
Dab2	NP_075607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PTB_Dab	35..171	CDD:269926
		Required for localization to clathrin-coated pits	230..447		50/213 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..482		28/124 (23%)
		PHA03247	<288..608	CDD:223021	27/120 (23%)
		DPF 1	293..295		1/1 (100%)
		DPF 2	298..300		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630
		Sufficient for interaction with GRB2. /evidence=ECO:0000269\|PubMed:9569023	600..730
		Required for interaction with CSK. /evidence=ECO:0000250	617..625
		Required for interaction with MYO6. /evidence=ECO:0000269\|PubMed:11906161	647..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..683
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	661..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..766
		Sufficient for interaction with SH3KBP1 SH3 domain	707..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930