Protein Alignment Aplip1 and mapk8ip1b

DIOPT Version :10

• Sequence 1: NP_728573.1
• Gene: Aplip1 / 53472
• FlyBaseID: FBgn0040281
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: XP_009301942.1
• Gene: mapk8ip1b / 100333948
• ZFINID: ZDB-GENE-170525-1
• Length: 670
• Species: Danio rerio
• Alignment Length: 467
• Identity: 145/467 - (31%)
• Similarity: 220/467 - (47%)
• Gaps: 116/467 - (24%)

  Fly    86 KVTLSSDGSLDTNDSFNSHRHHPLNHQD-------AIGGFLGMDTSGLGGNSAPVTIGASTDLLA 143
            ||.:|||          |....|.:.||       :....|.:|:|   |:..|..    .||..
Zfish   258 KVMVSSD----------SEAPPPYSEQDLQPPSYFSCVEALAVDSS---GDEEPTV----DDLCY 305

  Fly   144 PNTAATRRRRKLPEIPKNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCG 208
            .:..|.........:||     |:|           ....|....|:          |:.|:|..
Zfish   306 RDCGAGEAHAHHENLPK-----IIH-----------TSMSNSDASGL----------SYDSVKYT 344

  Fly   209 YLMDEDSSPDSERMQSLGDVDSGHS-TAHSP----------------------NDFKSMSP---- 246
            .::||.   |...:.||.:...|:| .:.||                      ||.:.:|.
Zfish   345 LVVDEH---DQLELVSLKECYRGYSDDSESPTVYDNCVSSPYESGLDKEYEEENDGEKLSRIKAS 406

  Fly   247 -QITSPVSQSPFPPPFGGV------------PFGQLEML------EATHRGLHKFVPRHHDEIEL 292
             :.::|.:..||...|..|            .||....|      |.|||.:::|:|||.||:||
Zfish   407 FEDSTPEADIPFSRKFVNVFMNGCSRSSSTESFGLFSCLINGEEREQTHRAVYRFIPRHDDELEL 471

  Fly   293 EIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKK----ERYLLGYLG 353
            |:.|.:.|:.:.||.|.||.|:|||.:||||:.||.:: :.|.:.....||.    |:|.:.:||
Zfish   472 ELNDPLLVELQDEDYWYEGYNMRTGARGIFPAYYATEV-FREQELASDEVKSSEWVEKYTMKFLG 535

  Fly   354 SVETLAHKGTGVVCQAVRKI-----VGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPC 413
            ||:.:.|||..|:|.|::||     :..:.|.|:  :||||::.:||::.     .|:..|....
Zfish   536 SVQVMNHKGNDVLCAAMQKIAMNRRLTVHYNPPS--SCILEITVKGLKLT-----VQDDFDMSSQ 593

  Fly   414 IDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFI 478
            ..:|:.|||||||.:|||:.::.|||||||..:|||||||....||:|:||:|.:||..:|::|:
Zfish   594 YSHFFHLKNVSFCGYHPRNKKYFGFITKHPADERFACHVFVSENSTKPLAESVRKAFHLYYKEFV 658

  Fly   479 ETAYPIEDIYIE 490
            |.:.|.||||:|
Zfish   659 EVSCPTEDIYLE 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	29/53 (55%)
		PTB_JIP	343..490	CDD:269923	66/155 (43%)
mapk8ip1b	XP_009301942.1	SH3_JIP1	454..508	CDD:212876	29/53 (55%)
		PTB_JIP	525..670	CDD:269923	65/151 (43%)