Protein Alignment Aplip1 and mapk8ip2

DIOPT Version :10

• Sequence 1: NP_728573.1
• Gene: Aplip1 / 53472
• FlyBaseID: FBgn0040281
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_001090670.1
• Gene: mapk8ip2 / 100036643
• XenbaseID: XB-GENE-484342
• Length: 1016
• Species: Xenopus tropicalis
• Alignment Length: 540
• Identity: 162/540 - (30%)
• Similarity: 239/540 - (44%)
• Gaps: 114/540 - (21%)

  Fly    44 DLEDSHSSKSD--GDGSDQEDGIGLVDHEP---KMRQVEDDELGDGLKVTLSSDGSLDTNDSFNS 103
            |||...|:..|  .:....:..|.|||.|.   .:..:|.::.|..|.|...|..::.......|
 Frog   498 DLETEFSASKDMSAELETTDQSIELVDMETLQNSLNHLEKEDAGPALYVMHDSCDTVTPIYEGLS 562

  Fly   104 HRHHPLNH-------------------------QDAIGGF---LGMDTSGLGGNSAPVTIGASTD 140
            |....|:|                         |:...|:   ..:|:..|..|.....:....|
 Frog   563 HHLEQLSHTAKCRTQSPVHRSEQKLWNGRQETMQEPADGWDIDRDLDSGILVDNDLCDDLCQELD 627

  Fly   141 LLAP----NTAATRRRRKLPEI-PKNKKSSILHLLGGSNFGS--LADEFRNGGGGGIPPAVRS-- 196
            ...|    :||.|.|...|... .|:.:.|....|..|.|.:  :.:.|..      ||...:
 Frog   628 QSQPSLDISTAKTNRGFNLEYTGEKDDEISYYRSLKNSPFENCVVEENFLE------PPLTETRL 686

  Fly   197 -GQQRSFLSLKCGYLMDEDSSPDSERMQSLGDVDSGHS---TAHSP-----NDF--------KSM 244
             ....::.|:|...::||.:..:...:|....:.|..|   |..:|     :||        :..
 Frog   687 MDDSLAYDSVKYTLVVDEHTQLELVSLQRCTSILSDGSDLLTTCNPCDLEEDDFGDEVDAQEQES 751

  Fly   245 SPQITSPVSQSPFPPPFGGV------------PFGQL------EMLEATHRGLHKFVPRHHDEIE 291
            |...:||....||...|..|            .||..      |..|.|||.:.:|:|||.||:|
 Frog   752 SSGDSSPEPNMPFSKKFLNVFVNSTSRSSSTDSFGLFSCVINGEEREQTHRAVFRFIPRHEDELE 816

  Fly   292 LEIGDAIYVQKEAED-LWCEGVNLRTGRQGIFPSAYA----------VDLDYNEFDPTVQLVKKE 345
            |::.|.:.|  |.|| .||.|.|:|||.:|||||.||          |.|..|  .|.||:...:
 Frog   817 LDVDDPLLV--ECEDGSWCRGYNMRTGERGIFPSFYAHEVVCPVKENVVLRGN--SPWVQMFDAQ 877

  Fly   346 RYLLGYLGSVETLAHKGTGVVCQAVRKI-----VGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQ 405
                 :|||||...|:|.|::|.|::||     :..:...|.  :|.||:|.:|::::.|.  |.
 Frog   878 -----FLGSVEVPNHQGNGILCAAMQKIATARKLTVHLRPPA--SCELEISLRGVKLILRG--ND 933

  Fly   406 NKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAF 470
            ..:|:: | .:|:.:||:|||..|||:..:.|||||||.:.|||||||...:|.|.|||.:||||
 Frog   934 RPEDER-C-SHFFQMKNISFCGCHPRNSCYFGFITKHPVLNRFACHVFVSQDSMRRVAECLGRAF 996

  Fly   471 QRFYQKFIETAYPIEDIYIE 490
            |.|||:.:|.:.|.||||:|
 Frog   997 QEFYQENVEFSCPTEDIYLE 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aplip1	NP_728573.1	SH3_JIP1_like	275..329	CDD:212735	30/64 (47%)
		PTB_JIP	343..490	CDD:269923	64/151 (42%)
mapk8ip2	NP_001090670.1	SH3	800..853	CDD:473055	30/54 (56%)
		PTB_JIP	870..1016	CDD:269923	66/156 (42%)