DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP555 and SPSB2

DIOPT Version :9

Sequence 1:	NP_001260073.1	Gene:	SP555 / 53471	FlyBaseID:	FBgn0260470	Length:	301	Species:	Drosophila melanogaster
Sequence 2:	NP_001139788.1	Gene:	SPSB2 / 84727	HGNCID:	29522	Length:	263	Species:	Homo sapiens

Alignment Length:	271	Identity:	70/271 - (25%)
Similarity:	107/271 - (39%)	Gaps:	64/271 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SSSTSPPPRFCP---LPNGVED-------------NWTWSKRHRSKEVVLRGPNSRTVHFHPN-W 92
            ||||..|....|   .|.|:|:             ...|:.:..|:.:.::   ...::|... .
Human    10 SSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK---EGGLYFERRPV 71

  Fly    93 SKGTAGVQGKRSLNNGRHYWELH--VSQRVFGTSIMFGIGTKSARLHANAFRNMLGENEHGWGLS 155
            ::.|.|.:|||..:.|.|.||:.  :.||  ||..:.|:.|..|.|..:.:..:||.|...||..
Human    72 AQSTDGARGKRGYSRGLHAWEISWPLEQR--GTHAVVGVATALAPLQTDHYAALLGSNSESWGWD 134

  Fly   156 -HKGVLWHEGV---ALLYTKRFRENQ---PTQIGVLFDGIEGTLTFYKDGKCLGVAFRGLDQIDE 213
             .:|.|:|:..   |..|....:..|   |.::.|:.|..||||.:...|..||.|||||.  ..
Human   135 IGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLK--GR 197

  Fly   214 PLYPIVCSTAAKTEMTLK------------------CTRREFVNLQDRCRAVIMRRVRSAAQLEK 260
            .|||.|.:...:.::.::                  |.|.   ||.|          ....|:..
Human   198 TLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRH---NLGD----------TRLGQVSA 249

  Fly   261 LKLPLPIADYL 271
            |.||..:..||
Human   250 LPLPPAMKRYL 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP555	NP_001260073.1	SPRY_SOCS3	64..249	CDD:293936	55/212 (26%)
SP555	NP_001260073.1	SOCS	240..273	CDD:295349	8/32 (25%)
SPSB2	NP_001139788.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		9/37 (24%)
		SPRY_SOCS1-2-4	46..217	CDD:293963	50/177 (28%)
		SOCS_SSB2	222..263	CDD:239689	11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810