DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP555 and SPCC1259.12c

DIOPT Version :9

Sequence 1:	NP_001260073.1	Gene:	SP555 / 53471	FlyBaseID:	FBgn0260470	Length:	301	Species:	Drosophila melanogaster
Sequence 2:	NP_588068.2	Gene:	SPCC1259.12c / 2538867	PomBaseID:	SPCC1259.12c	Length:	491	Species:	Schizosaccharomyces pombe

Alignment Length:	219	Identity:	51/219 - (23%)
Similarity:	84/219 - (38%)	Gaps:	43/219 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PNGVEDNWTWSKRHRSKE-------VVLRGPNSRTVHFHPNWSKGTAGVQGKRSL--NNGRHYWE 113
            |..:..:|..:.:..|.|       |...||.:.|.|       ..|.|:...::  |...:|:|
pombe    68 PKAIPSSWNPNDKSDSLELMNNNMGVYFFGPEAGTEH-------DAASVKADHAIPSNTSIYYYE 125

  Fly   114 LHVSQRVFGTSIMFGIGTKSARLHANAFRNMLGENEHGWGL-SHKGVLWH---EGVALLYTKRFR 174
            :.:..|  |.....|:|.....:..|.......|:   ||. .:.|..::   .|.|  |...|.
pombe   126 IQILSR--GKEGKMGVGFCRKSMQTNRLPGCTAES---WGYHGNSGEKFNCSKTGEA--YGPEFT 183

  Fly   175 ENQPTQIGVLFDGIEGTLTFYKDGKCLGVAFRGLDQIDEPLYPIVCSTAAKTEMTLKCTRREFVN 239
            .......||.|  |..|:.:.|:|..|||||:   ::.:.|||::...:....:.:...:..|
pombe   184 TGDIIGCGVNF--INRTIFYTKNGAYLGVAFK---KVSDVLYPVIGLKSHGEHVEVNFGQNPF-- 241

  Fly   240 LQDRCRAVIMRRVRSAAQLEKLKL 263
            |.|         :..|.|:||.||
pombe   242 LYD---------IDYAIQMEKNKL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP555	NP_001260073.1	SPRY_SOCS3	64..249	CDD:293936	44/197 (22%)
SP555	NP_001260073.1	SOCS	240..273	CDD:295349	8/24 (33%)
SPCC1259.12c	NP_588068.2	SPRY_RanBP9_10	102..238	CDD:293966	35/154 (23%)
		LisH	274..299	CDD:285685
		CTLH	308..361	CDD:128914
		CLTH	309..470	CDD:287564
		CRA	381..475	CDD:214806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910