DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP555 and FBXO45

DIOPT Version :9

Sequence 1:	NP_001260073.1	Gene:	SP555 / 53471	FlyBaseID:	FBgn0260470	Length:	301	Species:	Drosophila melanogaster
Sequence 2:	NP_001099043.1	Gene:	FBXO45 / 200933	HGNCID:	29148	Length:	286	Species:	Homo sapiens

Alignment Length:	291	Identity:	75/291 - (25%)
Similarity:	108/291 - (37%)	Gaps:	90/291 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IAAIAPRRRRPTG----RRGGVTGGLSSGSLDASSSTSPPPRF---------------CPLP--- 58
            :||.||.....:|    ..||...|..|||..|.:....|.|.               |.|.
Human     1 MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCALVCKH 65

  Fly    59 -----NGVEDNWTW-----------------------------------SKRHRSKEVVLRGPNS 83
                 :|.|::..|                                   |....|:.|.:: .|.
Human    66 WYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIK-KNG 129

  Fly    84 RTVHFHPNWSKGTAGVQGKRSLNNGRHYWELHVSQRVFGTSIMFGIGTKSARLHANAFRNMLGEN 148
            .|:|.:| .::.|.|.:.|...:.|||.||:. .:...||..:.||.||.|.:....:..:||.:
Human   130 FTLHRNP-IAQSTDGARTKIGFSEGRHAWEVW-WEGPLGTVAVIGIATKRAPMQCQGYVALLGSD 192

  Fly   149 EHGWG-------LSHKGVLWHEGVALLYTKRFRE--NQPT-QIG----VLFDGIEGTLTFYKDGK 199
            :..||       |.|.|.:         ...|.:  |.|. |||    |:.|..:.||.|.:..:
Human   193 DQSWGWNLVDNNLLHNGEV---------NGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYE 248

  Fly   200 CLGVAFRGLDQIDEPLYPIVCSTAAKTEMTL 230
            .||||||||.::  .|||.|.:....||:||
Human   249 FLGVAFRGLPKV--CLYPAVSAVYGNTEVTL 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP555	NP_001260073.1	SPRY_SOCS3	64..249	CDD:293936	57/216 (26%)
SP555	NP_001260073.1	SOCS	240..273	CDD:295349
FBXO45	NP_001099043.1	F-box-like	38..83	CDD:372399	7/44 (16%)
FBXO45	NP_001099043.1	SPRY_Fbox	112..286	CDD:293964	56/180 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810