DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLK1 and SAK

DIOPT Version :10

Sequence 1:NP_005021.2 Gene:PLK1 / 5347 HGNCID:9077 Length:603 Species:Homo sapiens
Sequence 2:NP_649324.1 Gene:SAK / 40384 FlyBaseID:FBgn0026371 Length:769 Species:Drosophila melanogaster


Alignment Length:585 Identity:175/585 - (29%)
Similarity:268/585 - (45%) Gaps:80/585 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDN 123
            |||||||..::.....|.:..|.|::.|.|:.......::..|:.||..|.|..|:..:.||:|.
  Fly    20 LGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDA 84

Human   124 DFVFVVLELCRRRSLLELHKR----RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFL 184
            ::|::||||....   |||:.    .:..||.||...|:|:|.|..|||.:.::|||:.|.||.|
  Fly    85 NYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLL 146

Human   185 NEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKP 249
            :.::.|||.||||||:::...||..|:|||||||:|||:|:..|....||||:||::||||||:|
  Fly   147 SREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRP 211

Human   250 PFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF----TSGY- 309
            ||||..::.|..::..:||.:|.|::..|..||.|:|:..|..|.|:..:|...|.    ..|: 
  Fly   212 PFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHS 276

Human   310 IPARLPITCLTIPPRFS--IAPSSLDPSNRKPL-TVLNKGLENPLPERPREKEEPV-----VRET 366
            .|..|.:...::....|  |..:|.|..|.:.: :|.|.|.:..||: .||:.:.|     ..:|
  Fly   277 APGALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQ-IREEFKQVHHKLPYEQT 340

Human   367 GEVVDCHLSDMLQQLHSVNASKPS----ERGLVRQEE----AEDPACIPIFWVSKWVD--YSDKY 421
            |  :....|..|.:.:...|:|.|    |.|.|...:    .||...:|.....:.:.  |..|.
  Fly   341 G--LFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISVPPLNTKRLLPTRYKTKN 403

Human   422 GLGYQLCDNSVGVLF------------NDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMK 474
            .:...|.:..|.:.|            ||..|  :.:||..:...:.|.... |.|...|..|..
  Fly   404 AIMSILRNGEVVLEFLKFRPTYNEDRINDICR--ISDDGQRIIIYQPDPGRG-LPVREQPPDLQI 465

Human   475 KITLLKY-FRNYMSEHLLK--AGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQ 536
            ......| :.|..|:|..|  .||...   |...::.|.: |:|.|.....|..:....:|.|:.
  Fly   466 PSGDCVYNYDNLPSKHWKKYIYGARFV---GLVKSKTPKV-TYFSTLGKCQLMETMTDFEIRFYS 526

Human   537 DHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGC----------------CKELASRLRYART 585
            . .||:..|......| |...       .||.:|.|                |..:::.|..|:|
  Fly   527 G-AKLLKTPSEGLKVY-DRNG-------MLLSDYSCSESRSLIEHGNECFTHCVNISNALEVAQT 582

Human   586  585
              Fly   583  582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLK1NP_005021.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
STKc_PLK1 45..309 CDD:271089 103/257 (40%)
Activation loop 194..221 16/26 (62%)
D-box that targets the protein for proteasomal degradation in anaphase 337..340 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 338..364 8/31 (26%)
POLO_box_1 407..494 CDD:240561 21/103 (20%)
Linker 493..507 3/13 (23%)
POLO_box_2 509..590 CDD:240560 20/93 (22%)
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 538..540 0/1 (0%)
SAKNP_649324.1 STKc_PLK4 12..267 CDD:271088 102/249 (41%)
POLO_box_Plk4_1 382..497 CDD:240557 25/120 (21%)
POLO_box_Plk4_2 498..596 CDD:240558 20/95 (21%)
POLO_box_Plk4_3 657..738 CDD:240559
Blue background indicates that the domain is not in the aligned region.

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