| Sequence 1: | NP_005021.2 | Gene: | PLK1 / 5347 | HGNCID: | 9077 | Length: | 603 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_649324.1 | Gene: | SAK / 40384 | FlyBaseID: | FBgn0026371 | Length: | 769 | Species: | Drosophila melanogaster |
| Alignment Length: | 585 | Identity: | 175/585 - (29%) |
|---|---|---|---|
| Similarity: | 268/585 - (45%) | Gaps: | 80/585 - (13%) |
- Green bases have known domain annotations that are detailed below.
|
Human 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDN 123
Human 124 DFVFVVLELCRRRSLLELHKR----RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFL 184
Human 185 NEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKP 249
Human 250 PFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF----TSGY- 309
Human 310 IPARLPITCLTIPPRFS--IAPSSLDPSNRKPL-TVLNKGLENPLPERPREKEEPV-----VRET 366
Human 367 GEVVDCHLSDMLQQLHSVNASKPS----ERGLVRQEE----AEDPACIPIFWVSKWVD--YSDKY 421
Human 422 GLGYQLCDNSVGVLF------------NDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMK 474
Human 475 KITLLKY-FRNYMSEHLLK--AGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQ 536
Human 537 DHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGC----------------CKELASRLRYART 585
Human 586 585 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| PLK1 | NP_005021.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..35 | ||
| STKc_PLK1 | 45..309 | CDD:271089 | 103/257 (40%) | ||
| Activation loop | 194..221 | 16/26 (62%) | |||
| D-box that targets the protein for proteasomal degradation in anaphase | 337..340 | 0/2 (0%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 338..364 | 8/31 (26%) | |||
| POLO_box_1 | 407..494 | CDD:240561 | 21/103 (20%) | ||
| Linker | 493..507 | 3/13 (23%) | |||
| POLO_box_2 | 509..590 | CDD:240560 | 20/93 (22%) | ||
| Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 | 538..540 | 0/1 (0%) | |||
| SAK | NP_649324.1 | STKc_PLK4 | 12..267 | CDD:271088 | 102/249 (41%) |
| S_TKc | 14..267 | CDD:214567 | 102/249 (41%) | ||
| POLO_box_Plk4_1 | 382..497 | CDD:240557 | 25/120 (21%) | ||
| POLO_box_Plk4_2 | 498..596 | CDD:240558 | 20/95 (21%) | ||
| POLO_box_Plk4_3 | 657..738 | CDD:240559 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG0575 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D507604at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.820 | |||||