DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Nkx6-1

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_113925.1	Gene:	Nkx6-1 / 65193	RGDID:	69318	Length:	365	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	150/373 - (40%)
Similarity:	187/373 - (50%)	Gaps:	119/373 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 SFL--GPPLAALHSMTTEMK-----------GQGVGGSSASANGLSY------SHSPNSHLISDR 336
            :||  .||||||||| .|||           ..|...||:|::..|.      :|:|..  :...
  Rat    14 AFLLSSPPLAALHSM-AEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPLGAHNPGG--LKPP 75

  Fly   337 GSGGSSSSSSTTTTNTNSQGAPNPHGIDTILSKPP-PV------------------------TSA 376
            .:||.||..|.    .....|..||||:.|||:|. ||                        |||
  Rat    76 AAGGLSSLGSP----PQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASATSA 136

  Fly   377 GLSALTG---------------AGIPRFS---------------IAAAAAGMAQYLSQSQGAPLK 411
            ..:|...               ||:||||               .|||.|.:.:|     ..||.
  Rat   137 SAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRY-----PKPLA 196

  Fly   412 THAGHIVDRTHLYWPGLQGLVANPIAWRE-RLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSG 475
            ...|    ||.::||   |::.:| .||: ||:.|       .||.....|||||:|||||||||
  Rat   197 ELPG----RTPIFWP---GVMQSP-PWRDARLACT-------PHQGSILLDKDGKRKHTRPTFSG 246

  Fly   476 QQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDD-- 538
            ||||||||||||||||||||||:|||:|||:|||||||||||||||||:|||||||||:|||.
  Rat   247 QQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSET 311

  Fly   539 --MGG-----DNDGDCSETMD--SDNESLDMGESPAQNKRCRSNSSGS 577
              :.|     ::|.|.::.:|  ||:|.:      .|..:...:|.||
  Rat   312 ERLKGTSENEEDDDDYNKPLDPNSDDEKI------TQLLKKHKSSGGS 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	43/155 (28%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	50/53 (94%)
Nkx6-1	NP_113925.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..136		24/106 (23%)
		Repressor domain. /evidence=ECO:0000250	102..269		71/186 (38%)
		Homeobox	240..294	CDD:395001	50/53 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..365		23/65 (35%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		13/53 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5762
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001882
OrthoInspector	1	1.000	-	-		otm46415
orthoMCL	1	0.900	-	-		OOG6_109928
Panther	1	1.100	-	-	LDO	PTHR24340
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810