DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and otx2

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_012823826.1	Gene:	otx2 / 548931	XenbaseID:	XB-GENE-485220	Length:	306	Species:	Xenopus tropicalis

Alignment Length:	211	Identity:	51/211 - (24%)
Similarity:	78/211 - (36%)	Gaps:	73/211 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 KPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVA 433
            |.||....|||..|             :|| ..|..|.|.|:..|
Frog     6 KQPPYAVNGLSLTT-------------SGM-DLLHPSVGYPVALH-------------------- 36

  Fly   434 NPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPE--- 495
                        .|..::.|.....:..:  |::..|.||:..|:..||..|.:|:|   |:
Frog    37 ------------QSRQITCSFYDFAATPR--KQRRERTTFTRAQLDVLEALFAKTRY---PDIFM 84

  Fly   496 RAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDGDCSETMDSDNESLDM 560
            |.::|..:.:.||:|:|||:|||.|.|:         :::|...||.|....|:..
Frog    85 REEVALKINLPESRVQVWFKNRRAKCRQ---------QQQQQQNGGQNKVRPSKKK--------- 131

  Fly   561 GESPAQNKRCRSNSSG 576
             .|||:.....|.:||
Frog   132 -PSPAREVSSESGTSG 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	7/18 (39%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	22/56 (39%)
otx2	XP_012823826.1	Homeobox	59..111	CDD:365835	22/54 (41%)
otx2	XP_012823826.1	TF_Otx	170..251	CDD:367546
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910