Protein Alignment HGTX and NKX1-1

DIOPT Version :9

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 97/448 - (21%)
• Similarity: 141/448 - (31%)
• Gaps: 166/448 - (37%)

  Fly   177 DSPSTTPPPASSRLHSDSSPSPRYEHNSSPGVDSAKSYALSQRS-------SGAEDPCQTSESAS 234
            |.|:..|||     ...|.|:|       |...:|...|:..|:       :|| .|...|::..
Human    11 DIPALPPPP-----QPGSGPAP-------PAPAAAAQEAMDGRAELPAFPRAGA-PPLAASDTVP 62

  Fly   235 PPPQG-----------QNDYS------PENLSSQRAKFQHHHGVNPL------------------ 264
            ..|:|           ...:|      |...:|:|.:......|.|.
Human    63 AAPEGAGAARPAAPLRPTSFSVLDILDPNKFNSRRRRCVLLGPVAPAACAPCASAPCAPAPAASG 127

  Fly   265 -----------ALHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGSSAS 318
                       ||..|...|..|....|           .|.|..|..:.|.:..|...||...|
Human   128 RPPRAEELERRALAGAGGVGAAGAEPPN-----------AGDPFKAGEAETNDTNGYSSGGGGHS 181

  Fly   319 ANGLSYSHSPNSH------------------------LISDRGSG--GSSSSSSTTTTNTNSQGA 357
            .:..|....|:..                        .:..||||  |::.:.::.....:...|
Human   182 PSADSGDEVPDDEDDDEDEAPETEAARGAEEARGGGGGLGARGSGCQGAAETDASPGATVDEAAA 246

  Fly   358 PNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTH 422
            |.|.....:...||    .|.:|..|||......|.||            .|.:...|
Human   247 PGPRENSPVAQGPP----GGAAAPGGAGTTPQGTATAA------------KPKRKRTG------- 288

  Fly   423 LYWPGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQ 487
                                                |:.|.||.:..|..|:.:|:.|||..|:.
Human   289 ------------------------------------SDSKSGKPRRARTAFTYEQLVALENKFKA 317

  Fly   488 TKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDG 545
            |:||:..||..||.:|.::|:|||:|||||||||:|::.....:|...    ||...|
Human   318 TRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTG----GGGGPG 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	54/287 (19%)
		Homeobox	469..523	CDD:395001	28/53 (53%)
NKX1-1	NP_001277008.1	Homeobox	300..352	CDD:278475	27/51 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910