DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and NKX6-1

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_006159.2	Gene:	NKX6-1 / 4825	HGNCID:	7839	Length:	367	Species:	Homo sapiens

Alignment Length:	371	Identity:	150/371 - (40%)
Similarity:	187/371 - (50%)	Gaps:	117/371 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 SFL--GPPLAALHSMTTEMK-----------GQGVGGSSASANGLSY------SHSPNSHLISDR 336
            :||  .||||||||| .|||           ..|...||:|::..|.      :|:|..  :...
Human    14 AFLLSSPPLAALHSM-AEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGG--LKPP 75

  Fly   337 GSGGSSSSSSTTTTNTNSQGAPNPHGIDTILSKPP-PVTS------------------------- 375
            .:||.||..|.    .....|..||||:.|||:|. ||.|
Human    76 ATGGLSSLGSP----PQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSA 136

  Fly   376 -----------AGLSALTG--AGIPRFS---------------IAAAAAGMAQYLSQSQGAPLKT 412
                       |..|:..|  ||:||||               .|||.|.:.:|     ..||..
Human   137 SAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRY-----PKPLAE 196

  Fly   413 HAGHIVDRTHLYWPGLQGLVANPIAWRE-RLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQ 476
            ..|    ||.::||   |::.:| .||: ||:.|       .||.....|||||:||||||||||
Human   197 LPG----RTPIFWP---GVMQSP-PWRDARLACT-------PHQGSILLDKDGKRKHTRPTFSGQ 246

  Fly   477 QIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDD--- 538
            |||||||||||||||||||||:|||:|||:|||||||||||||||||:|||||||||:|||.
Human   247 QIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETE 311

  Fly   539 -MGG-----DNDGDCSETMD--SDNESLDMGESPAQNKRCRSNSSG 576
             :.|     :.|.|.::.:|  ||:|.:..     ..|:.:|:|.|
Human   312 RLKGASENEEEDDDYNKPLDPNSDDEKITQ-----LLKKHKSSSGG 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	43/154 (28%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	50/53 (94%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..133		24/102 (24%)
		Repressor domain. /evidence=ECO:0000250	102..268		71/185 (38%)
		Homeobox	239..293	CDD:395001	50/53 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..367		23/64 (36%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5911
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001882
OrthoInspector	1	1.000	-	-		otm42262
orthoMCL	1	0.900	-	-		OOG6_109928
Panther	1	1.100	-	-	LDO	PTHR24340
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.810