Protein Alignment HGTX and MSX2

DIOPT Version :10

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_002440.2
• Gene: MSX2 / 4488
• HGNCID: 7392
• Length: 267
• Species: Homo sapiens
• Alignment Length: 210
• Identity: 54/210 - (25%)
• Similarity: 87/210 - (41%)
• Gaps: 40/210 - (19%)

  Fly   337 GSGGSSSSSSTTTTNTNSQGAPNPHGIDTILS-KPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQ 400
            |.||:..::.......:|.    |..::.::| |.||..::.|.|         ..|:|.|.:..
Human    27 GPGGAEGAAEERRVKVSSL----PFSVEALMSDKKPPKEASPLPA---------ESASAGATLRP 78

  Fly   401 YLSQSQGAPLKTHAGHIV------------DRTHLYWPGLQGLVANPIAWRERLSNTMSANLSQS 453
            .|....||......|.:|            ......|....|..:.|.......:.|:
Human    79 LLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTL------- 136

  Fly   454 HQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRR 518
             :.|.:|.|      .|..|:..|:.|||:.|.|.:||:..|||:.:.:|.::|:|||:||||||
Human   137 -RKHKTNRK------PRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRR 194

  Fly   519 TKWRKRHAAEMATAK 533
            .|.::...||:...|
Human   195 AKAKRLQEAELEKLK 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	11/51 (22%)
		Homeodomain	465..523	CDD:459649	25/57 (44%)
MSX2	NP_002440.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..147		6/44 (14%)
		Homeodomain	143..199	CDD:459649	26/61 (43%)