DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and dlx5

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001004778.1	Gene:	dlx5 / 447997	XenbaseID:	XB-GENE-853057	Length:	289	Species:	Xenopus tropicalis

Alignment Length:	218	Identity:	56/218 - (25%)
Similarity:	90/218 - (41%)	Gaps:	60/218 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 GAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTMSANL-----------SQSHQHH--- 457
            ||....|.|:....:..|     |...|...::....|..:.|.           |..|.||
Frog    46 GAAGHPHHGYCSPTSATY-----GKALNAYQYQYHGMNGAAGNYPGKAYSDYGYGSPYHPHHQYS 105

  Fly   458 --------PS---------------NDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKL 499
                    ||               |.|..|.:..|..:|..|:.||::.|::|:|||.||||:|
Frog   106 GAYNRVQPPSSQPEKEVSEPEVRMVNGKPKKIRKPRTIYSSFQLAALQRRFQKTQYLALPERAEL 170

  Fly   500 AYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDGDCSETMDSDNESLDMGESP 564
            |.:||::::|||:||||:|:|.:|         ..|..::..::....|:.|..::....:...|
Frog   171 AASLGLTQTQVKIWFQNKRSKIKK---------IMKNGELPPEHSPSSSDPMACNSPQSPVVWEP 226

  Fly   565 AQNKRCRSN---------SSGSS 578
            ..:.|..|:         :||||
Frog   227 QGSSRSLSHHPHVHSHPQASGSS 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	27/53 (51%)
dlx5	NP_001004778.1	DLL_N	26..118	CDD:315147	15/76 (20%)
dlx5	NP_001004778.1	Homeobox	140..193	CDD:306543	27/52 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910