DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HGTX and tin

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	116/540 - (21%)
Similarity:	182/540 - (33%)	Gaps:	190/540 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 RHHLAAAMSNGFADVHAH-----AMAAAD---------------------YQQQLADYHSAAAAA 139
            :||...|.|.|:.|.:..     ::..||                     |:........||.|:
  Fly     3 QHHQQQAQSGGYYDHYTQSPSPGSLTNADALNTTPFSVKDILNMVNQTEAYEGSYGHIDGAATAS 67

  Fly   140 AVYANNNNNNNNNSSNNNNSSPLMLLKAAHGGGLKDSDSPSTTPPPASSRLHSDSSPSPRYEHNS 204
            |::|.....|.:...|:                  .....|..|.| ..:||        ::|
  Fly    68 ALFAAGEYQNPHQYLNH------------------QQHQQSELPIP-QQQLH--------HQH-- 103

  Fly   205 SPGVDSAKSYALSQRSSGAEDPCQTSESAS----PPPQ----GQNDYS-PENLSSQRAKFQHHHG 260
                              .:|...||.|.|    |||.    |..||. |.::      |||||
  Fly   104 ------------------LDDGATTSSSLSPLLPPPPHQLYGGYQDYGMPAHM------FQHHH- 143

  Fly   261 VNPLALHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGSSASANGLSYS 325
                        |:|  |.:..|.             |:.::|:.   .|...|:||:|     .
  Fly   144 ------------GHP--HQSFQHS-------------ASAYNMSA---SQFYAGASATA-----Y 173

  Fly   326 HSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNPHGIDTILSKPPPV----TSAGLSALTGAGI 386
            .:|.::..:..|||.....::.:.....|:..|.|:      ..|.|.    :||.:.:|. |..
  Fly   174 QTPATYNYNYAGSGEVYGGATPSAVGIKSEYIPTPY------VTPSPTLDLNSSAEVDSLQ-APT 231

  Fly   387 PRFSI----------AAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRER 441
            .:..:          |:.::.:.......:||..|.::.....|:.|
  Fly   232 QKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKDNSQVTSSRSEL------------------ 278

  Fly   442 LSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMS 506
            ..|::|.|.:..  .:..:.|...|:..|..||..|:..||..|...|||.|.||..:|..|.:|
  Fly   279 RKNSISGNSNPG--SNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLS 341

  Fly   507 ESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDGDC---SETMDSDNESLDMGES---PA 565
            .:|||:||||||.|           :||        .|.||   ::.:...:|.||...|   |.
  Fly   342 ATQVKIWFQNRRYK-----------SKR--------GDIDCEGIAKHLKLKSEPLDSPTSLPPPI 387

  Fly   566 QNKRCRSNSSGSSQQQQDNY 585
            .|......:...|||||.::
  Fly   388 PNHVMWPPTMQQSQQQQQHH 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	47/221 (21%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	26/53 (49%)
tin	NP_524433.1	HOX	301..357	CDD:197696	27/66 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I4196
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D858478at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24340
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020