DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Noto

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001007473.1	Gene:	Noto / 384452	MGIID:	3053002	Length:	240	Species:	Mus musculus

Alignment Length:	241	Identity:	64/241 - (26%)
Similarity:	104/241 - (43%)	Gaps:	77/241 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 SSSSSSTTTTNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQS 405
            ::|...:|.|:.|..||.:.:|:      .|.|.|      ||:.:|    |..:.|:....|.|
Mouse    56 ATSLPLSTCTSLNLLGAVSQYGV------LPWVCS------TGSWLP----AYLSVGVYPLCSMS 104

  Fly   406 QGAPLKTHAGHIVDRTHLYWPGL------QGL---------VANPIAWRERLSNTMSANLSQSHQ 455
                              ..|||      |||         ...|:.|.
Mouse   105 ------------------CVPGLNVTHHQQGLRLTGSELPYCLGPLKWA---------------- 135

  Fly   456 HHPSND-KD-GKKKHT---RPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQ 515
              |:.| :| |.::||   |.||:.||:..|||.|.:...|.|.|||:||..|.::|:||::|||
Mouse   136 --PTVDLRDHGTERHTKRVRTTFNLQQLQELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQ 198

  Fly   516 NRRTKWRKRHAAEMATAKRKQDDMGGDNDGDCSETMDSDNESLDMG 561
            |||.|::|:...::.::. ..::....:||:    :.|::..|.:|
Mouse   199 NRRVKYQKQQKLKLPSSS-VMEEPSSSSDGN----IQSEDAELGIG 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	12/46 (26%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	28/56 (50%)
Noto	NP_001007473.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Homeobox	153..204	CDD:278475	26/50 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..240		5/37 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810