DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HGTX and vax2

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_919390.1	Gene:	vax2 / 373869	ZFINID:	ZDB-GENE-030904-8	Length:	307	Species:	Danio rerio

Alignment Length:	252	Identity:	58/252 - (23%)
Similarity:	87/252 - (34%)	Gaps:	101/252 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 SHSPNSHLISDRGSGGSS-----------SSSSTTTTNTNSQGAPNPHGIDTILSKPPPVTSAGL 378
            :|..::.|..|||....|           ||:.|..|:.::..:.:..|.|.:|...|...
Zfish    17 NHCGSNSLCRDRGRESKSRTEVGNRSPVQSSTDTPGTSASTPTSSSEDGHDKLLGVDPDYC---- 77

  Fly   379 SALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLS 443
                     |..:...|.|..:.:...:|..|        ||
Zfish    78 ---------RRILVRDAKGTIREIVLPKGLDL--------DR----------------------- 102

  Fly   444 NTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSES 508
                                  .|.||.:|:.:|::.||..|::.:|:.|.||.:||..|.:||:
Zfish   103 ----------------------PKRTRTSFTAEQLYRLELEFQRCQYVVGRERTELARQLNLSET 145

  Fly   509 QVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDGDCSETMDSDNESLDMGESPA 565
            ||||||||||||.:|                        .:|.|:|..|....||.|
Zfish   146 QVKVWFQNRRTKQKK------------------------DQTKDTDKRSSSTSESLA 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	14/73 (19%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	28/53 (53%)
vax2	NP_919390.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		12/52 (23%)
		Homeobox	106..159	CDD:278475	28/52 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..175		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..254
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810