DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HGTX and Nkx2-4

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_038962557.1	Gene:	Nkx2-4 / 366213	RGDID:	1304985	Length:	353	Species:	Rattus norvegicus

Alignment Length:	226	Identity:	60/226 - (26%)
Similarity:	93/226 - (41%)	Gaps:	52/226 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 TNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAA-----GMAQYLSQSQGAP 409
            |..:||.|       .:....||...||.:|...|.....:.||||.     |::|:...:.|:.
  Rat    52 TGPSSQAA-------AVAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHSAMGSY 109

  Fly   410 LKTHAGHIVDRTHLYWPGLQ-GLVANPIAW--------RERLSNTM------------------- 446
            .....|: :.....|..|:: |..|....|        ...:|..|
  Rat   110 CNGGLGN-MGELPAYTDGMRGGAAAAATGWYGANTDPRYSSISRFMGPSAGVNVAGMGSLTGIAD 173

  Fly   447 -SANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQV 510
             :.:|:..|...|       ::..|..||..|::.||:.|:|.|||:.|||..||..:.::.:||
  Rat   174 AAKSLAPLHAAAP-------RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQV 231

  Fly   511 KVWFQNRRTKWRKRHAAEMATAKRKQDDMGG 541
            |:||||.|.| .||.|.:.|..:.:|:  ||
  Rat   232 KIWFQNHRYK-MKRQAKDKAAQQLQQE--GG 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	10/37 (27%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	25/53 (47%)
Nkx2-4	XP_038962557.1	Homeobox	190..244	CDD:395001	25/54 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910