Protein Alignment HGTX and HOXD11

DIOPT Version :10

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_067015.2
• Gene: HOXD11 / 3237
• HGNCID: 5134
• Length: 338
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 75/363 - (20%)
• Similarity: 117/363 - (32%)
• Gaps: 107/363 - (29%)

  Fly   205 SPGVDSAKSYALSQRSSGAEDPCQT----SESASPPPQGQNDYSPENLSSQRAKFQHHHGVNPLA 265
            :|...::|...|||.||     ||.    |.:.:|..|...:.:..:...:|||:.:..|....:
Human    24 APSDFASKPSFLSQPSS-----CQMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGS 83

  Fly   266 LHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGG---------SSASANG 321
            ....:..|.||                              ..|.|.||         ::|:|..
Human    84 AGGGSSGGGPG------------------------------GGGGGAGGYAPYYAAAAAAAAAAA 118

  Fly   322 LSYSHSPNSHLISDRG---------------SGGSSSSSSTTTTNTNSQGAPN---PHGIDTIL- 367
            .:...:....|:...|               :.|.....:...:|..|....|   |.|.|...
Human   119 AAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYE 183

  Fly   368 ----------SKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTH 422
                      ..|||............|.||  ..|...|.:.....:.|:..|..|
Human   184 AAPGPPFAGPQPPPPPAPPQPEGAADKGDPR--TGAGGGGGSPCTKATPGSEPKGAA-------- 238

  Fly   423 LYWPGLQGLVANP--IAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTF 485
               .|..|....|  .|..|:.|:.::...|             :||  |..::..||..||:.|
Human   239 ---EGSGGDGEGPPGEAGAEKSSSAVAPQRS-------------RKK--RCPYTKYQIRELEREF 285

  Fly   486 EQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRK 523
            ....|:...:|.:|:..|.:::.|||:||||||.|.:|
Human   286 FFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	38/224 (17%)
		Homeodomain	465..523	CDD:459649	22/57 (39%)
HOXD11	NP_067015.2	DUF3528	26..185	CDD:432284	33/193 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..270		21/118 (18%)
		Homeodomain	267..323	CDD:459649	22/57 (39%)