Protein Alignment HGTX and HOXC11

DIOPT Version :10

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_055027.1
• Gene: HOXC11 / 3227
• HGNCID: 5123
• Length: 304
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 68/305 - (22%)
• Similarity: 103/305 - (33%)
• Gaps: 92/305 - (30%)

  Fly   232 SASPPPQGQNDYSPENLSSQRAKFQHHHGVNPLALHNANHAGNPGCHNNNNHMDHKLPLSFLGPP 296
            ||..||..:..|..|    ...|:.|.:..:             .|:...:.:.|:..|    ||
Human    64 SAQVPPVREVSYGLE----PSGKWHHRNSYS-------------SCYAAADELMHRECL----PP 107

  Fly   297 LAALHSMTTE--MKGQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPN 359
                 |..||  ||.:|..|.         .|.|::...:..|...|.:.:|..
Human   108 -----STVTEILMKNEGSYGG---------HHHPSAPHATPAGFYSSVNKNSVL----------- 147

  Fly   360 PHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLY 424
            |...|....          :|..|.|.|......:..|      :::|.|..
Human   148 PQAFDRFFD----------NAYCGGGDPPAEPPCSGKG------EAKGEPEA------------- 183

  Fly   425 WPGLQGLVANPIAWRERLSNTMSANLSQSHQHH-----------PSNDKDGKKKHTRPTFSGQQI 478
             |...||.:...|..|..:...:.|.|.|...|           |:..:..||   |..:|..||
Human   184 -PPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPNAPRTRKK---RCPYSKFQI 244

  Fly   479 FALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRK 523
            ..||:.|....|:...:|.:|:..|.:::.|||:||||||.|.:|
Human   245 RELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	30/157 (19%)
		Homeodomain	465..523	CDD:459649	23/57 (40%)
HOXC11	NP_055027.1	DUF3528	42..161	CDD:432284	28/152 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..237		15/93 (16%)
		Homeodomain	233..289	CDD:459649	23/58 (40%)