Protein Alignment HGTX and HOXC8

DIOPT Version :10

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_073149.1
• Gene: HOXC8 / 3224
• HGNCID: 5129
• Length: 242
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 80/319 - (25%)
• Similarity: 118/319 - (36%)
• Gaps: 94/319 - (29%)

  Fly   261 VNPL-ALHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGSSASANGLSY 324
            |||| :.:.|..:..|.      :.|.:.|.|     :...|::.     .|.|||:.     .:
Human     6 VNPLFSKYKAGESLEPA------YYDCRFPQS-----VGRSHALV-----YGPGGSAP-----GF 49

  Fly   325 SHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNP-----HGIDTILSKPPPVTSAGLSALTG- 383
            .|:  ||.:.|....|:|..|       ||....||     ||              ..|...|
Human    50 QHA--SHHVQDFFHHGTSGIS-------NSGYQQNPCSLSCHG--------------DASKFYGY 91

  Fly   384 AGIPRFSI--AAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTM 446
            ..:||.|:  |...|.:.||......|...:..|             ||          .|:...
Human    92 EALPRQSLYGAQQEASVVQYPDCKSSANTNSSEG-------------QG----------HLNQNS 133

  Fly   447 SANL--SQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQ 509
            |.:|  .....|.|.      ::..|.|:|..|...|||.|....||....|.::::|||::|.|
Human   134 SPSLMFPWMRPHAPG------RRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQ 192

  Fly   510 VKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDNDGDCSETMDSDNESLDMGESPAQNK 568
            ||:||||||.||:|         :..:|.:.|..|.:..|...::.|..: .|...:||
Human   193 VKIWFQNRRMKWKK---------ENNKDKLPGARDEEKVEEEGNEEEEKE-EEEKEENK 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	29/133 (22%)
		Homeodomain	465..523	CDD:459649	26/57 (46%)
HOXC8	NP_073149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..154		9/68 (13%)
		Antp-type hexapeptide	138..143		0/4 (0%)
		Homeodomain	150..206	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..242		9/46 (20%)