Protein Alignment HGTX and TLX2

DIOPT Version :9

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_057254.1
• Gene: TLX2 / 3196
• HGNCID: 5057
• Length: 284
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 87/287 - (30%)
• Similarity: 109/287 - (37%)
• Gaps: 91/287 - (31%)

  Fly   273 GNPGCHNNNNHMDHKLPLSF------LGPPLAALHSMTTEMKGQGVG-GSSASANGLSYSHSPNS 330
            |..|.||    :.|..|:||      .||          |..|.|:| |.....:|.:.:.|...
Human     4 GMLGPHN----LPHHEPISFGIDQILSGP----------ETPGGGLGLGRGGQGHGENGAFSGGY 54

  Fly   331 HLISDRGSGGSSSSSSTTTTNTNSQGAPNPHGIDTI-----LSKPPPVTSA----GLSALTGAGI 386
            |..|..|..||.:..      ..|.|. .|.|:..:     |..|||...|    |.|.|.|||
Human    55 HGASGYGPAGSLAPL------PGSSGV-GPGGVIRVPAHRPLPVPPPAGGAPAVPGPSGLGGAG- 111

  Fly   387 PRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAW--------RERLS 443
                                                    ||.||.   ..|        ::||:
Human   112 ----------------------------------------GLAGLT---FPWMDSGRRFAKDRLT 133

  Fly   444 NTMSANLSQSHQHHP-SNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSE 507
            ..:|.........|| .|....|:|..|.:||..|:..||:.|.:.||||..|||.||.||.|::
Human   134 AALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTD 198

  Fly   508 SQVKVWFQNRRTKWRKRHAAEMATAKR 534
            :|||.|||||||||| |..||...|:|
Human   199 AQVKTWFQNRRTKWR-RQTAEEREAER 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	37/130 (28%)
		Homeobox	469..523	CDD:395001	31/53 (58%)
TLX2	NP_057254.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		16/59 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..106		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..166		7/26 (27%)
		Homeobox	160..213	CDD:278475	30/52 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870