Protein Alignment HGTX and Nkx6-2

DIOPT Version :10

• Sequence 1: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001101028.1
• Gene: Nkx6-2 / 309095
• RGDID: 1307280
• Length: 277
• Species: Rattus norvegicus
• Alignment Length: 298
• Identity: 130/298 - (43%)
• Similarity: 158/298 - (53%)
• Gaps: 78/298 - (26%)

  Fly   284 MDHKLPLSFL--GPPLAALHSMTTEMKG-------QGVGGSSASANGLSYSHSPNSHLISDRGSG 339
            ||...|.:|:  ..||||||:| .|||.       ||..|....|                .||.
  Rat     1 MDANRPGAFVLSSAPLAALHNM-AEMKTSLFPYALQGPAGFKTPA----------------LGSL 48

  Fly   340 GSSSSSSTTTTNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGM----AQ 400
            |:.....|            ||||..||.:|......||.    ..:||.:..|::||:    |.
  Rat    49 GAQLPLGT------------PHGISDILGRPVGAAGGGLL----GSLPRLNGLASSAGVYFGPAA 97

  Fly   401 YLSQSQGAPLKTHAGHIVDRTHLYWPG-LQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDG 464
            .:::....||....|    |..::||| :||   :|  ||:       ..|:.|.|.....||||
  Rat    98 AVARGYPKPLAELPG----RPPIFWPGVVQG---SP--WRD-------PRLAGSAQAGGVLDKDG 146

  Fly   465 KKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEM 529
            ||||:||||||||||||||||||||||||||||:|||:|||:|||||||||||||||||||||||
  Rat   147 KKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEM 211

  Fly   530 ATAKRKQDDMGGDNDGDCSETMDSDNESLDMGESPAQN 567
            |:||:||               |||.|.|.:|.|.|::
  Rat   212 ASAKKKQ---------------DSDAEKLKVGGSDAED 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	31/112 (28%)
		Homeodomain	465..523	CDD:459649	53/57 (93%)
Nkx6-2	NP_001101028.1	Homeodomain	147..205	CDD:459649	53/57 (93%)