DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Nkx2-8

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001100202.1	Gene:	Nkx2-8 / 299061	RGDID:	1310629	Length:	234	Species:	Rattus norvegicus

Alignment Length:	192	Identity:	48/192 - (25%)
Similarity:	69/192 - (35%)	Gaps:	68/192 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 QGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDG------------------------KKKHT 469
            |..|....||           |.....|:||:|:.|                        |::..
  Rat    31 QTCVPQTAAW-----------LESERSHYPSSDESGLETSPADSSQLASLGRASPGSDAEKRRKR 84

  Fly   470 RPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKR 534
            |..||..|...||:.|.|.:||:.|||.:||..|.::.:|||:||||.|.|.::..|..:
  Rat    85 RVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQVKIWFQNHRYKLKRGRAPGV----- 144

  Fly   535 KQDDMGGDNDGDCSETMDSD-NESLDMGESPAQNKR------------CRSNSSGSSQQQQD 583
                           |..|| ..|.|:..:|...:|            |.....|::...||
  Rat   145 ---------------TESSDVTASADLHAAPGLLRRVVVPVLVHDRSPCNGRGEGTAAVPQD 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	25/53 (47%)
Nkx2-8	NP_001100202.1	Homeobox	84..137	CDD:278475	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840