DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and Alx1

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_766141.1	Gene:	Alx1 / 216285	MGIID:	104621	Length:	326	Species:	Mus musculus

Alignment Length:	190	Identity:	49/190 - (25%)
Similarity:	78/190 - (41%)	Gaps:	48/190 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 LSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPI------AWRERLSNTMSANLSQSHQHHPSN 460
            :::.:|.||.|.....:|..:       .|..:|:      :..:.|.:...:|:|.|
Mouse    80 ITKVEGQPLHTELNRAMDNCN-------NLRMSPVKGMPEKSELDELGDKCDSNVSSS------- 130

  Fly   461 DKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRH 525
                ||:..|.||:..|:..|||.|::|.|.....|.:||....::|::|:|||||||.|||||
Mouse   131 ----KKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKR- 190

  Fly   526 AAEMATAKRKQDDMGGDNDGDCSETMDSDNESLDMGESP-------AQNKRCRSNSSGSS 578
                            :..|...:.......:.|:...|       .||.....|:||.|
Mouse   191 ----------------ERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGS 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	24/53 (45%)
Alx1	NP_766141.1	Homeobox	135..189	CDD:395001	24/53 (45%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		9/43 (21%)
		OAR	302..320	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910