DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HGTX and DLX3

DIOPT Version :9

Sequence 1:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_005211.1	Gene:	DLX3 / 1747	HGNCID:	2916	Length:	287	Species:	Homo sapiens

Alignment Length:	211	Identity:	58/211 - (27%)
Similarity:	93/211 - (44%)	Gaps:	57/211 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 NSHLISDRGSGGSSSSSSTTTTNTNSQGAP-------NPHGIDTILSKPPPVT---SAGLSALTG 383
            :|.|....||..|.:...::.|:.....||       .|:| .|:    .|.|   ...|:.|.|
Human    17 SSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYG-QTV----NPYTYHHQFNLNGLAG 76

  Fly   384 AGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTMSA 448
            .|        |.:..::|   :.||..:.:.                      |:||:   .:.|
Human    77 TG--------AYSPKSEY---TYGASYRQYG----------------------AYREQ---PLPA 105

  Fly   449 NLSQSHQHHPS------NDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSE 507
            ....|.:..|.      |.|..|.:..|..:|..|:.||::.|::.:|||.||||:||..||:::
Human   106 QDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQ 170

  Fly   508 SQVKVWFQNRRTKWRK 523
            :|||:||||||:|::|
Human   171 TQVKIWFQNRRSKFKK 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	17/68 (25%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	27/53 (51%)
DLX3	NP_005211.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39		4/18 (22%)
		DLL_N	27..107	CDD:403572	21/120 (18%)
		COG5576	<109..232	CDD:227863	33/78 (42%)
		homeobox	129..188		28/58 (48%)
		Homeobox	132..186	CDD:395001	27/53 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810