DRSC/TRiP Functional Genomics Resources

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Protein Alignment HGTX and DLX2

DIOPT Version :9

Sequence 1:NP_001368954.1 Gene:HGTX / 53446 FlyBaseID:FBgn0040318 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_004396.1 Gene:DLX2 / 1746 HGNCID:2915 Length:328 Species:Homo sapiens


Alignment Length:274 Identity:73/274 - (26%)
Similarity:110/274 - (40%) Gaps:50/274 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 SMTTEMKGQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNPHGIDT- 365
            |:..:|....:..||      :|............|.||:|||||:......|...|.....|: 
Human     7 SLVADMHSTQIAASS------TYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSS 65

  Fly   366 -ILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQG---APLKTHAGHIVDRTHLYWP 426
             ..::..|....|     |.|.|       .|.|..|..|:.|   .|....:.:.:..|..|..
Human    66 YYTNQQHPAGGGG-----GGGSP-------YAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTS 118

  Fly   427 ----GLQGLVANPIAWRERLSNTMSANLSQSHQHHPS----NDKDGKKKHTRPTFSGQQIFALEK 483
                |.....||              |..:.....|.    |.|..|.:..|..:|..|:.||::
Human   119 YAPYGTSSSPAN--------------NEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQR 169

  Fly   484 TFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKR-HAAEMATAKRKQDDMGGDNDGDC 547
            .|::|:|||.||||:||.:||::::|||:||||||:|::|. .:.|:.:    :...|......|
Human   170 RFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPS----EQHPGASASPPC 230

  Fly   548 SETMDSDNESLDMG 561
            :....|...|.|.|
Human   231 ASPPVSAPASWDFG 244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HGTXNP_001368954.1 ROM1 179..>388 CDD:227709 20/87 (23%)
Homeobox 469..523 CDD:395001 28/53 (53%)
DLX2NP_004396.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..81 17/75 (23%)
DLL_N 51..132 CDD:289198 19/106 (18%)
Homeobox 155..208 CDD:278475 28/52 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..270 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..328
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0850
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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